Recent Development of Advanced Biotechnology in the Oleaginous Fungi for Arachidonic Acid Production

Li, Ya-Wen; Guo, Qi; Peng, Qianqian; Shen, Qi; Nie, Zhi-Kui; Ye, Chao; Shi, Tian‐Qiong

doi:10.1021/acssynbio.2c00483

Cited by 3 publications

(1 citation statement)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the Mortierella alpina fungus, the ARA is 80% with respect to the total lipids, but it requires long culture periods, i.e., two weeks, to reach this value [ 29 , 30 , 31 ]. Bacterial strains Shwenella sp.…”

Section: Introductionmentioning

confidence: 99%

Screening and Identification of Coastal Chilean Thraustochytrids for Arachidonic Acid Production: Biotechnological Potential of Ulkenia visurgensis Lng2-Strain

et al. 2023

View full text Add to dashboard Cite

Thraustochytrids are unicellular heterotrophic marine protists that have been described as producing a high content of polyunsaturated fatty acids (PUFAs). Among them, arachidonic acid (ARA) stands out as a precursor of several mediators of pivotal importance for the immune system. However, the biotechnological potential of thraustochytrids for ARA production has not been developed. The objective of this study is to isolate and identify native strains from different Chilean coastal environments and evaluate in vitro the effect of culture parameters such as C/N ratio (19 and 33) and temperature (15 °C and 23 °C) on biomass production and arachidonic acid content. A total of nine strains were identified and classified into four genera of the Thraustochitridae family. The Lng2 strain with 99% identity belongs to the species Ulkenia visurgenis and was the most prominent one for ARA production. Temperature had an effect on the PUFA profile but not on the ARA content nor on the biomass yield. Additionally, the C/N ratio has been identified as a key parameter. The ARA productivity increased by 92% (from 0.6 to 8.3 ARA mg/g-DW) and its total biomass by 62.7% (from 1.9 to 5.1 g/L) at a high C/N ratio (33) as compared to the control.

show abstract

Section: Introductionmentioning

confidence: 99%

Screening and Identification of Coastal Chilean Thraustochytrids for Arachidonic Acid Production: Biotechnological Potential of Ulkenia visurgensis Lng2-Strain

et al. 2023

View full text Add to dashboard Cite

show abstract

Universal and unique strategies for the production of polyunsaturated fatty acids in industrial oleaginous microorganisms

Yan,

Zhang,

Yang

et al. 2024

Biotechnology Advances

View full text Add to dashboard Cite

Oleaginous Microbial Lipids’ Potential in the Prevention and Treatment of Neurological Disorders

Alhattab,

Moorthy,

Patel

et al. 2024

Marine Drugs

View full text Add to dashboard Cite

The products of oleaginous microbes, primarily lipids, have gained tremendous attention for their health benefits in food-based applications as supplements. However, this emerging biotechnology also offers a neuroprotective treatment/management potential for various diseases that are seldom discussed. Essential fatty acids, such as DHA, are known to make up the majority of brain phospholipid membranes and are integral to cognitive function, which forms an important defense against Alzheimer’s disease. Omega-3 polyunsaturated fatty acids have also been shown to reduce recurrent epilepsy seizures and have been used in brain cancer therapies. The ratio of omega-3 to omega-6 PUFAs is essential in maintaining physiological function. Furthermore, lipids have also been employed as an effective vehicle to deliver drugs for the treatment of diseases. Lipid nanoparticle technology, used in pharmaceuticals and cosmeceuticals, has recently emerged as a biocompatible, biodegradable, low-toxicity, and high-stability means for drug delivery to address the drawbacks associated with traditional medicine delivery methods. This review aims to highlight the dual benefit that lipids offer in maintaining good health for disease prevention and in the treatment of neurological diseases.

show abstract

Recent Development of Advanced Biotechnology in the Oleaginous Fungi for Arachidonic Acid Production

Cited by 3 publications

References 89 publications

Screening and Identification of Coastal Chilean Thraustochytrids for Arachidonic Acid Production: Biotechnological Potential of Ulkenia visurgensis Lng2-Strain

Screening and Identification of Coastal Chilean Thraustochytrids for Arachidonic Acid Production: Biotechnological Potential of Ulkenia visurgensis Lng2-Strain

Universal and unique strategies for the production of polyunsaturated fatty acids in industrial oleaginous microorganisms

Oleaginous Microbial Lipids’ Potential in the Prevention and Treatment of Neurological Disorders

Contact Info

Product

Resources

About