Recent Dengue Infection in Bangladesh: A Seasonal Endemic Progressing to Year-long Serious Health Concern

Al Mahtab, Mamun; Mahtab, Musarrat; Rahim, Md Abdur; Akbar, Sheikh Mohammad Fazle; Khan, Sakirul; Yahiro, Takaaki; Arafat, Shohael Mahmud; Sarker, Mohammad Abdus Sattar; Podder, Provat Kumar; Hossain, Mohammad Shawkat; Khandokar, Faiz Ahmad; Hassan, Mohammad Rashedul; Ashraf, Muhammad Ali; Rony, Rajib Saha; Nishizono, Akira

doi:10.5005/jp-journals-10018-1408

Euroasian Journal of Hepato-Gastroenterology

2023

DOI: 10.5005/jp-journals-10018-1408

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Recent Dengue Infection in Bangladesh: A Seasonal Endemic Progressing to Year-long Serious Health Concern

Mamun Al Mahtab,

Musarrat Mahtab,

Md Abdur Rahim

et al.

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2024

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Cited by 2 publications

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Reduced protein-coding transcript diversity in severe dengue emphasises the role of alternative splicing

Mehta,

Liu,

Sinha

et al. 2024

Life Sci. Alliance

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Dengue fever, a neglected tropical arboviral disease, has emerged as a global health concern in the past decade. Necessitating a nuanced comprehension of the intricate dynamics of host–virus interactions influencing disease severity, we analysed transcriptomic patterns using bulk RNA-seq from 112 age- and gender-matched NS1 antigen–confirmed hospital-admitted dengue patients with varying severity. Severe cases exhibited reduced platelet count, increased lymphocytosis, and neutropenia, indicating a dysregulated immune response. Using bulk RNA-seq, our analysis revealed a minimal overlap between the differentially expressed gene and transcript isoform, with a distinct expression pattern across the disease severity. Severe patients showed enrichment in retained intron and nonsense-mediated decay transcript biotypes, suggesting altered splicing efficiency. Furthermore, an up-regulated programmed cell death, a haemolytic response, and an impaired interferon and antiviral response at the transcript level were observed. We also identified the potential involvement of theRBM39gene among others in the innate immune response during dengue viral pathogenesis, warranting further investigation. These findings provide valuable insights into potential therapeutic targets, underscoring the importance of exploring transcriptomic landscapes between different disease sub-phenotypes in infectious diseases.

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Reduced protein-coding transcript diversity in severe dengue emphasises the role of alternative splicing

Mehta,

Liu,

Sinha

et al. 2024

Life Sci. Alliance

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An effective pan-serotype dengue vaccine and enhanced control strategies could help in reducing the severe dengue burden in Bangladesh–A perspective

Kayesh,

Nazneen,

Kohara

et al. 2024

Front. Microbiol.

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Dengue is an important vector-borne disease occurring globally. Dengue virus (DENV) infection can result in a potentially life-threatening disease. To date, no DENV-specific antiviral treatment is available. Moreover, an equally effective pan-serotype dengue virus vaccine is not available. Recently, two DENV vaccines, Dengvaxia and Qdenga, were licensed for limited use. However, none of them have been approved in Bangladesh. DENV is transmitted by Aedes mosquitoes, and global warming caused by climate change favoring Aedes breeding plays an important role in increasing DENV infections in Bangladesh. Dengue is a serious public health concern in Bangladesh. In the year 2023, Bangladesh witnessed its largest dengue outbreak, with the highest number of dengue cases (n = 321,179) and dengue-related deaths (n = 1,705) in a single epidemic year. There is an increased risk of severe dengue in individuals with preexisting DENV-specific immunoglobulin G if the individuals become infected with different DENV serotypes. To date, vector control has remained the mainstay for controlling dengue; therefore, an immediate, strengthened, and effective vector control program is critical and should be regularly performed for controlling dengue outbreaks in Bangladesh. In addition, the use of DENV vaccine in curbing dengue epidemics in Bangladesh requires more consideration and judgment by the respective authority of Bangladesh. This review provides perspectives on the control and prevention of dengue outbreaks. We also discuss the challenges of DENV vaccine use to reduce dengue epidemics infection in Bangladesh.

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Recent Dengue Infection in Bangladesh: A Seasonal Endemic Progressing to Year-long Serious Health Concern

Cited by 2 publications

References 52 publications

Reduced protein-coding transcript diversity in severe dengue emphasises the role of alternative splicing

Reduced protein-coding transcript diversity in severe dengue emphasises the role of alternative splicing

An effective pan-serotype dengue vaccine and enhanced control strategies could help in reducing the severe dengue burden in Bangladesh–A perspective

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