Recent corticosteroid use and recent disease activity: Independent determinants of coronary heart disease risk factors in systemic lupus erythematosus?

Karp, Igor; Abrahamowicz, Michał; Fortin, Paul R.; Pilote, Louise; Neville, Carolyn; Pineau, Christian; Esdaile, John M.

doi:10.1002/art.23352

Cited by 95 publications

(80 citation statements)

References 46 publications

(43 reference statements)

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“…The role of the glucocorticoids in the pathogenesis of atherosclerosis is controversial 40 . This study found no significant relation of the prednisone cumulative dose and IMT index.…”

Section: Discussionmentioning

confidence: 99%

Intima media thickness measurement as a marker of subclinical atherosclerosis in SLE patient

Smrzova¹,

Horák²,

Skácelová³

et al. 2014

BIOMED PAP

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Aim. Accelerated atherosclerosis in systemic lupus erythematosus (SLE) is an important cause of morbidity and mortality. The pathophysiology of accelerated atherosclerosis in SLE is mediated by factors such as inflammatory processes in the vascular wall, specific antibodies, dyslipoproteinemia, endothelial dysfunction and the high prevalence of traditional risk factors for cardiovascular diseases. In this context, we evaluated the clinical significance of ultrasound examination of the carotic arteries in the early diagnosis of atherosclerosis. Methods. The study included 63 patients with SLE (female: male 53:10, mean age 38.4±12.7 years, mean disease duration 143.0 ±82.6 months), 24 patients had lupus nephritis. The control group consisted of 24 volunteers (female: male 20:4 mean age 31.04±8.59). Intima media thickness (IMT) was measured by ultrasound on both sides. The results were correlated with markers of lipid spectrum, anti-dsDNA, antinucleosomal and anticardiolipin antibodies, lupus anticoagulant and complement components. Clinical disease activity and damage were evaluated by SLEDAI and SLICC indices. Lifestyle and other important factors were examined per protocol and by questionnaire. Results. A significant difference of IMT (P≤0.03) was found between the lupus patients and sex-age adjusted healthy controls with an in mean IMT in SLE patients of 0.569±0.11 mm, in control group 0.495±0.05 mm. A significant correlation between IMT and disease duration, age, positivity of lupus anticoagulant, use of ACE inhibitors, glomerular filtration and serum creatinine were found. No difference in IMT was found between patients with or without lupus nephritis. Conclusion. IMT measurement could be used as a clinical predictor of risk of accelerated atherosclerosis in lupus patients.

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“…The role of the glucocorticoids in the pathogenesis of atherosclerosis is controversial 40 . This study found no significant relation of the prednisone cumulative dose and IMT index.…”

Section: Discussionmentioning

confidence: 99%

Intima media thickness measurement as a marker of subclinical atherosclerosis in SLE patient

Smrzova¹,

Horák²,

Skácelová³

et al. 2014

BIOMED PAP

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show abstract

“…(Manzi et al 1997, Roman et al, 2003 A six-point increase in the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score over 1 year correlated with a 5% increase in a 2-year CV risk. (Karp et al, 2008) This same increase in SLEDAI score was associated with increases of 3.4 mmHg in systolic blood pressure, 1 mg/dl in glucose and 11.6 mg/dl in TG as well as a 2.3-mg/dl decrease in HDL cholesterol. In the study performed by Roman and colleagues, the diagnosis of SLE itself, a longer duration of disease and greater disease damage (measured by SLICCDamage Index [SLICC-DI]) were independent predictors of carotid plaque.…”

Section: Disease Activitymentioning

confidence: 77%

Cardiovascular Involvement in Systemic Lupus Erythematosus

Abdulaziz¹,

Al-Ghamdi²,

Samannodi³

et al. 2012

Systemic Lupus Erythematosus

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“…Ibanez, et al have shown that for every 1-unit increase in the time-adjusted mean SLE disease activity index 2000 (SLEDAI-2K) score, the hazard of a CHD event increases 1.08-fold (hazard ratio 1.08, 95% CI 1.00, 1.16, p = 0.046) 8 . Karp, et al have also shown that recent lupus disease activity measured using the SLEDAI-2K correlates with higher values of several well recognized coronary risk factors and overall 2-year CHD risk 9 .…”

Section: Rheumatologymentioning

confidence: 95%

Guilt by Association: The Challenge of Teasing Apart the Effect of Various Risk Factors for Coronary Heart Disease in Systemic Lupus Erythematosus

Nikpour¹

2010

J Rheumatol

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Recent corticosteroid use and recent disease activity: Independent determinants of coronary heart disease risk factors in systemic lupus erythematosus?

Cited by 95 publications

References 46 publications

Intima media thickness measurement as a marker of subclinical atherosclerosis in SLE patient

Intima media thickness measurement as a marker of subclinical atherosclerosis in SLE patient

Cardiovascular Involvement in Systemic Lupus Erythematosus

Guilt by Association: The Challenge of Teasing Apart the Effect of Various Risk Factors for Coronary Heart Disease in Systemic Lupus Erythematosus

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