Recent cohort trends in malignant melanoma by anatomic site in the United States

Dennis, Leslie K.; White, Emily; Lee, John A. H.

doi:10.1007/bf00053149

Cited by 49 publications

(31 citation statements)

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“…36 Our results are in agreement with several other studies showing that melanoma tends to occur most often on the trunk in white males and on the lower limb in white females. 18,20,[40][41][42][43][44][45][46] Gender differences in patterns of detection and knowledge regarding melanoma have been previously studied. This study, and others, show that women are more likely to discover their own lesions.…”

Section: Figurementioning

confidence: 99%

Trends in Invasive Cutaneous Melanoma in Saskatchewan 1970?1999

Ulmer

Tonita

Hull

2003

Journal of Cutaneous Medicine and Surgery: Incorporating Medica

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Section: Figurementioning

confidence: 99%

Trends in Invasive Cutaneous Melanoma in Saskatchewan 1970?1999

Ulmer

Tonita

Hull

2003

Journal of Cutaneous Medicine and Surgery: Incorporating Medica

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“…[1][2][3] Since the mid-1980s, however, the rates of increase began decreasing or at least leveling off. [4][5][6][7][8][9] Recent studies showed that the observed leveling-off in rates predominantly occurred in younger persons and the patterns showed positive effects for cohorts born after 1945 or 1950. 4,6,9 Conversely, the rate of increase in melanoma incidence and mortality has been significantly higher for age groups older than 60 years in Europe, the US, and Australia.…”

mentioning

confidence: 99%

Age and gender are significant independent predictors of survival in primary cutaneous melanoma

Lasithiotakis¹,

Leiter²,

Meier³

et al. 2008

Cancer

229

178

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BACKGROUNDThe aim was to identify age‐ related and gender‐related differences in the clinical presentation and outcome of patients with primary cutaneous melanoma (CM).METHODSA total of 4785 CM patients without clinical evidence of metastasis diagnosed during the period 1976–2001 in southern Germany included in the analysis. Kaplan‐Meier analyses were performed to estimate and to compare disease‐specific survival (DSS) and survival after first recurrence (SAR). The Cox proportional hazards model was used to evaluate the effect of multiple variables on DSS and SAR.RESULTSIncreasing age and male gender were independently associated with thicker tumors (>2 mm) and histologic ulceration (P < .001). Patients older than 65 years had lower 10‐year DSS than younger patients (81.8% vs 88.4%, P < .001) and this difference was more pronounced in women (P < .001) than in men (P = .06). Males had lower 10‐year DSS than females (83.5% vs 88.5%, P < .001) but this difference did not reach statistical significance in patients older than 65 years (P = .162). In multivariate analysis adjusted for tumor thickness, ulceration, anatomic site, histologic subtype, DSS, site of first recurrence, time trend, sentinel lymph node status, age, and gender were independent predictors of DSS and SAR (P < .05).CONCLUSIONSOlder age and male gender are associated with prognostically unfavorable primary CM. Expansion of current preventive strategies to target these subgroups is warranted. Moreover, age and gender are independent predictors of the outcome of CM patients. Females have a better prognosis than males but this difference disappears after the age of 65. Younger patients have a more favorable prognosis than older patients, a difference more pronounced in women. Cancer 2008. © 2008 American Cancer Society.

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“…Descriptive studies of malignant melanoma time trends have shown significant anatomic site and gender differences (Chen et al, 1994;Dennis et al, 1993;Thorn et al, 1990). These differences have generally been attributed to anatomic siteand gender-specific differences in time trends in patterns of sun exposure, a consequence of changes in clothing fashions and recreational habits.…”

mentioning

confidence: 99%

Malignant melanoma risk factors by anatomic site: A case-control study and polychotomous logistic regression analysis

et al. 1996

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This population-based case-control study systematically examined reported malignant melanoma risk factors by anatomic site. Study subjects consisted of 548 invasive melanoma cases diagnosed in Connecticut during 1987-1989 and 494 randomly selected controls. Multivariate polychotomous logistic regression was used to determine whether risk factors differed across anatomic sites. Risk factors examined included demographic and pigmentary characteristics, sun exposure-related factors, anatomic site-specific sunburn, recreational water activity clothing habits and number of nevi. A pattern of site-specificity w a s observed for sunburn. A history of sunburn at an anatomic site was specifically related to the development of malignant melanoma at that site more so than at other sites. This sitespecificity was consistent with a direct role for intense, intermittent sun exposure in the development of melanoma. Age and gender were the only risk factors that differed significantly in effect across anatomic sites. The age difference was explained by differences in histologic subtype across sites. The gender difference could not be explained by sex differences in anatomic site-specific sunburns or in recreational water activity clothing habits. Alternative explanations include sex differences in behavioral patterns of sun exposure that we did not measure and as yet unelucidated differences in susceptibility to melanoma according to sex and anatomic site.o 1996 Wiley-Liss, Inc.The determinants of the anatomic site distribution of cutaneous malignant melanoma are not well understood. Descriptive studies of malignant melanoma time trends have shown significant anatomic site and gender differences (Chen et al., 1994;Dennis et al., 1993;Thorn et al., 1990). These differences have generally been attributed to anatomic siteand gender-specific differences in time trends in patterns of sun exposure, a consequence of changes in clothing fashions and recreational habits. However, only a limited number of analytical epidemiologic studies have examined malignant melanoma risk factors by anatomic site (Elwood et al., 1984; Green et al., 1986;Swerdlow et al., 1986; Holman et a/., 1986;Weinstock et al., 1989Weinstock et al., , 1991Kruger et al., 1992;Cress et al., 1995). Most examined only a small number of risk factors, and only 1 (Elwood et al., 1984) tested the statistical significance of differences across anatomic sites.The current investigation systematically examined reported malignant melanoma risk factors by anatomic site using data from a population-based case-control study. The major hypothesis was that the risk of malignant melanoma would vary across anatomic sites according to site-specific sun exposure and clothing habits, while host-related risk factors (e.g., sex, age, skin color, tanning ability) would not differ across anatomic sites.been interviewed as part of a case-control study of skin examination and lethal melanoma (Benvick et al., 1996).All incident first primary cases of cutaneous malignant melanoma (invasive and...

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Recent cohort trends in malignant melanoma by anatomic site in the United States

Cited by 49 publications

References 32 publications

Trends in Invasive Cutaneous Melanoma in Saskatchewan 1970?1999

Trends in Invasive Cutaneous Melanoma in Saskatchewan 1970?1999

Age and gender are significant independent predictors of survival in primary cutaneous melanoma

Malignant melanoma risk factors by anatomic site: A case-control study and polychotomous logistic regression analysis

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