Recent chemical synthesis and immunological evaluation of glycans related to bacterial lipopolysaccharides

Chemical Synthesis of a Densely Functionalized Aminodisaccharide from Fusobacterium nucleatum ATCC 23726 O-Antigen

“…Consequently, developing a safe and effective prophylactic or therapeutic vaccine against F. nucleatum could be beneficial in treating CRC. Carbohydrate-based vaccines have been extensively employed in preventing diseases caused by diverse pathogenic bacteria . However, the development of carbohydrate-based vaccines against F. nucleatum has been hampered by challenges in identifying promising carbohydrate antigens.…”

“…Carbohydrate-based vaccines have been extensively employed in preventing diseases caused by diverse pathogenic bacteria. 4 However, the development of carbohydrate-based vaccines against F. nucleatum has been hampered by challenges in identifying promising carbohydrate antigens. The chemical synthesis of homogeneous and well-defined oligosaccharides has become an essential foundation for protective epitope identification of carbohydrate antigens.…”

Chemical Synthesis of an Orthogonally Protected 5,7-Diamino-3,5,7,9-tetradeoxy-d-glycero-l-gluco-2-nonulosonic Acid from N-Acetylneuraminic Acid

“…Bacterial glycans perform essential roles in various biological processes, including host–pathogen interactions and immunoregulations . Thus, these glycans have been considered as essential targets for treating and preventing bacterial infections. , The biological functions of bacterial glycans are related to their structural diversity, which is enhanced by the presence of unusual monosaccharides and rare functional groups …”

“…However, further elucidation of the biological roles of these unusual NulOs has been hampered by challenges in procuring pure NulO-containing glycans. Chemical synthesis of well-defined and homogeneous oligosaccharides has laid an essential foundation for elucidating the structure–activity relationships of bioactive glycans . Nevertheless, chemical synthesis of unusual NulOs is challenging because of configuration control and regioselective modification and has been the main obstacle to preparing the related bacterial glycans.…”