Recent aspects of the stereochemistry of schiff-base-metal complexes

Yamada, Shoichiro

doi:10.1016/s0010-8545(00)80184-8

Cited by 264 publications

(44 citation statements)

References 30 publications

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“…Tetradentate Schiff-base ligands derived from salicylaldehyde and aliphatic amines are well known (14). Cobalt complexes of tetradentate Schiff-base ligands have been investigated as mimics of vitamin B 12 coenzymes and certain Co III Schiff-base complexes are known to have antiviral, antibacterial, and antitumor properties (15,16).…”

Section: Resultsmentioning

confidence: 99%

Cellular Up-regulation of Nedd4 Family Interacting Protein 1 (Ndfip1) using Low Levels of Bioactive Cobalt Complexes

Schieber

Howitt

Putz

et al. 2011

Journal of Biological Chemistry

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The delivery of metal ions using cell membrane-permeable metal complexes represents a method for activating cellular pathways. Here, we report the synthesis and characterization of new [ Transition metals are essential for many important chemical processes in biological systems. Most of these metal-related processes occur by interactions with nucleic acids and proteins. Within the cell, metal ions can stabilize, destabilize, or modulate DNA and proteins by introducing conformational changes and by creating centers of activity. Although the use of metals as structural elements within the cell is well known, emerging evidence now recasts metals as signaling molecules able to activate critical cellular pathways. For example, metals such as iron, copper, and cobalt can produce reactive oxygen species that lead to the activation of redox-sensitive transcription factors including NF-B, AP-1, and p53. Metals have also been suggested to affect the upstream regulatory components of the MAP kinase and the PI3K/Akt/mTor pathway (1, 2). Thus the levels and regulation of metals in a cell can have a direct role on cell function and survival.Metal ions such as Co II and Fe II can stimulate the expression of the neuroprotective protein Nedd4 family interacting protein 1 (Ndfip1) 4 in the brain (3). Ndfip1 is a transmembrane protein that is localized to the Golgi and post-Golgi vesicles such as endosomes (4, 5). Ndfip1 functions as an adaptor protein for the Nedd4 family of ubiquitin ligases that target proteins for both degradation and trafficking (4). The metal-induced up-regulation of Ndfip1 results in the activation of the ubiquitin proteasome pathway. Ndfip1 recognizes and interacts with divalent metal transporter 1 (DMT1), this recruits the E3 ligase Nedd4 -2 resulting in degradation of DMT1, preventing iron overload within the cell (3). Other targets for Ndfip1 have also been identified, including the transcription factor JunB that is regulated by Ndfip1 in association with the E3 ligase Itch (6). In the adult brain, Ndfip1 is endogenously present in cortical neurons at low levels, however it is up-regulated in a subset of neurons upon activation by injury or stress (7). Importantly, this up-regulation of Ndfip1 has been shown to be neuroprotective, and neurons with up-regulated Ndfip1 do not undergo apoptosis.Whereas high levels of exogenous Co II and Fe II are toxic to cells, our previous results show they also stimulate Ndfip1 via still unknown mechanisms. Barring the effects of metal toxicity, this finding introduces an opportunity to harness the capacity of metal ions to up-regulate Ndfip1 for neuroprotective purposes. In the present study, we investigate the utility of nontoxic metal complexes for controlled intracellular delivery of cobalt to stimulate Ndfip1 expression. This was based on the premise that the reactivity of metal ions can be modulated by the formation of coordination complexes, with a complexed 4 The abbreviations used are: Ndfip1, Nedd4 family interacting protein 1; DMT1, divalent metal transporte...

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Section: Resultsmentioning

confidence: 99%

Cellular Up-regulation of Nedd4 Family Interacting Protein 1 (Ndfip1) using Low Levels of Bioactive Cobalt Complexes

Schieber

Howitt

Putz

et al. 2011

Journal of Biological Chemistry

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“…Thermogravimetric analyses were carried out for Al [sal (CH2 -) 2) Infrared spectra: The infrared spectra of the ligands and the aluminium derivatives are very similar and complicated. The ligands show medium intensity broad bands ~ 3100 -3450 cm -1 due to hydrogen bonded OH or NH, which disappear on compound formation.…”

Section: Py F»acssmentioning

confidence: 99%

“…Metal derivatives of bidentate monofunctional and tetradentate bifunctional SCHIFF bases 2 have been known for a long time. The tridentate bifunctional Schiff base derivatives of a few transition metals [3][4][5] only have been studied during the last 3 -4 years, but there appears to be no reference in the literature on derivatives of these Schiff bases with non-transition trivalent elements.…”

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confidence: 99%

Aluminium Derivatives of Tridentate Bifunctional Schiff Bases Derived from Salicylaldehyde and Benzoylacetone

Dayal

Mehrotra

1972

Zeitschrift Für Naturforschung B

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“…These have several applications in organic studies, such as for building new heterocyclic systems, for identification, detection, and determination of aldehydes and ketones, for purification of carbonyl or amino compounds, or for the protection of these groups during the complex formation or such sensitive reactions [1]. They have other side applications in various other fields, coordination chemistry [2][3][4][5][6][7][8][9], analytical chemistry [10][11][12][13][14][15][16], pigments and dyes [17], and polymer industries [18], in vitamins and enzymes [4] for model biomolecules. There is a special mention of these complexes in agriculture [4] as fungicides, pesticides, and bacteriocides.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Complexes Synthesized Using Schiff Base Ligands and Their Screening for Toxicity Two Fungal and One Bacterial Species on Rice Pathogens

Mangamamba¹,

Ganorkar²,

Swarnabala

2014

International Journal of Inorganic Chemistry

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Coordination complexes with metal ions Cu(II), Ni(II), Co(II), Fe(III), Mn(II), Cr(III), and VO(II) with six ligands formed by condensation products using azides and aldehydes or ketones are characterized. Both the ligands and the complexes synthesized are characterized by C, H, N, Cl and metal analyses, IR, UV-Vis, TGA, and magnetic susceptibility for tentative structure proposal. Several of them are screened for their toxicity (i.e., physiological activity) against fungal species Rhizoctonia solani and Acrocylindrium oryzae and a bacterium, Xanthomonas oryzae on rice pathogens. The study shows that the observed physiological activity is enhanced for the metal complexes as compared to the simple metal salts or ligands, except in the case of L3 or HAEP ligand, where the free -OH and -NH 2 groups on the ligand seemed to have inhibited the activity. It is also observed that the order of activity has a dependence on the increased atomic weight of the metal ion in use. In some cases, especially the VO(II) complexes, they are found to be better than the standards in use, both for the fungicides and for the bactericide.

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Recent aspects of the stereochemistry of schiff-base-metal complexes

Cited by 264 publications

References 30 publications

Cellular Up-regulation of Nedd4 Family Interacting Protein 1 (Ndfip1) using Low Levels of Bioactive Cobalt Complexes

Cellular Up-regulation of Nedd4 Family Interacting Protein 1 (Ndfip1) using Low Levels of Bioactive Cobalt Complexes

Aluminium Derivatives of Tridentate Bifunctional Schiff Bases Derived from Salicylaldehyde and Benzoylacetone

Characterization of Complexes Synthesized Using Schiff Base Ligands and Their Screening for Toxicity Two Fungal and One Bacterial Species on Rice Pathogens

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