Recent Approaches in Insulin Delivery

Trehan, Anupam; Ali, Asgar

doi:10.3109/03639049809082359

Cited by 38 publications

(20 citation statements)

References 54 publications

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“…Besides PNI technology, there are many other potential approaches for alternative insulin administration, such as oral, pulmonary, buccal, nasal, and transdermal approaches (Trehan and Asgar, 1998). Oral administration of insulin offers relatively low bioavailability, ranging from 0.5% to 10.0% (Cui et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Needle-free injection of insulin powder: delivery efficiency and skin irritation assessment

Wang

et al. 2014

J. Zhejiang Univ. Sci. B

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Abstract:Insulin is widely used in treating diabetes, but still needs to be administered by needle injection. This study investigated a new needle-free approach for insulin delivery. A portable powder needleless injection (PNI) device with an automatic mechanical unit was designed. Its efficiency in delivering insulin was evaluated in alloxan-induced diabetic rabbits. The skin irritation caused by the device was investigated and the results were analyzed in relation to aerodynamic parameters. Inorganic salt-carried insulin powders had hypoglycemic effects, while raw insulin powders were not effective when delivered by PNI, indicating that salt carriers play an important role in the delivery of insulin via PNI. The relative delivery efficiency of phosphate-carried insulin powder using the PNI device was 72.25%. A safety assessment test showed that three key factors (gas pressure, cylinder volume, and nozzle distance) were related to the amount of skin irritation caused by the PNI device. Optimized injection conditions caused minimal skin lesions and are safe to use in practice. The results suggest that PNI has promising prospects as a novel technology for delivering insulin and other biological drugs.

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Section: Discussionmentioning

confidence: 99%

Needle-free injection of insulin powder: delivery efficiency and skin irritation assessment

Wang

et al. 2014

J. Zhejiang Univ. Sci. B

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“…1 In recent decades, oral delivery of insulin has been widely investigated because it can improve patient compliance and transport insulin directly to the liver, which can prevent peripheral hyperinsulinemia. 2 In addition, orally delivered insulin undergoes hepatic bypass before entering the circulation, so has the potential to mimic the effects of insulin secreted by the pancreas in terms of inhibition of hepatic gluconeogenesis and hepatic glucose output.…”

Section: Introductionmentioning

confidence: 99%

Hydrophobic ion pairing of an insulin-sodium deoxycholate complex for oral delivery of insulin

Cui¹

2011

IJN

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Insulin was complexed with sodium deoxycholate to form an insulin-sodium deoxycholate complex (Ins-SD-Comp) using an hydrophobic ion pairing method in aqueous phase to enhance the liposolubility of insulin. In order to obtain the maximal complexation efficiency, the molar ratio of sodium deoxycholate to insulin was found. The zeta potential method was used to confirm the optimal ratio for formation of Ins-SD-Comp. The structural characteristics of Ins-SD-Comp were assessed using the Fourier transform infrared method. The apparent partition coefficient of insulin increased upon the formation of Ins-SD-Comp. Based on the preliminary study, Ins-SD-Comp was encapsulated into poly(lactide-co-glycolide) (PLGA) nanoparticles using an emulsion solvent diffusion method. The maximal encapsulation efficiency of Ins-SD-Comp into PLGA nanoparticles was 93.6% ± 2.81%, drug loading was about 4.8% ± 0.32%, and the mean diameter of the nanoparticles was 278 ± 13 nm. Biological activity and in vivo results revealed that the bioactivity of insulin was not destroyed during the preparation process. Ins-SD-Comp-loaded PLGA nanoparticles have the potential to reduce serum glucose levels and increase the oral bioavailability of insulin.

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“…In recent years, extravascular administration of insulin, including oral, pulmonary, nasal, ocular and transdermal routes, etc. has attracted more and more attention from pharmaceutical scientists (Trehan & Ali, 1998;Khafagy et al, 2007). Oral dosing, with broad acceptance and cost-effectiveness, has been the focus of most concern to fulfill the expectation of a needle-free insulin treatment (Iyer et al, 2010;Bakhru et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Modified nanoparticles with cell-penetrating peptide and amphipathic chitosan derivative for enhanced oral colon absorption of insulin: preparation and evaluation

et al. 2015

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(2016) Modified nanoparticles with cell-penetrating peptide and amphipathic chitosan derivative for enhanced oral colon absorption of insulin: preparation and evaluation, Drug Delivery, 23:6, 2003-2014, DOI: 10.3109/10717544.2015 AbstractColon is an ideal absorptive site for oral protein and peptide drug (insulin), and yet it poses multiple barriers against the drug absorption, such as the barriers against the drug diffusion from colon lumen toward the absorptive mucosa and permeation across colon epithelium. In this study, modified nanoparticles (Tat-CS-NPs) with cell-penetrating peptide (Tat) and amphipathic chitosan derivative (a-CS) were used as carriers to improve colonic absorption of the drug. With a-CS as emulsifier and poly(lactic-co-glycolic acid) as matrix material, Tat-CS-NPs were prepared and evaluated in vitro/vivo. Using Caco-2 cell monolayers to imitate the colonic epithelial cells, it was found that the cellular uptake amount and transcellular transportation performance of Tat-CS-NPs were much enhanced compared with those of CS-NPs and PVA-NPs. The efficacy evaluation on diabetic rat models demonstrated that the hypoglycemic effect of Tat-CS-NPs loaded with insulin was 6.89 times higher than that of PVANPs, and 1.79 times higher than that of CS-NPs. By gavage of [ 99m Tc] isotope labeled Tat-CS-NPs in mini-pigs and single-photon emission computed tomography (SPECT) on pigs' gastrointestinal tract, it was further proved that the nanoparticles could reach colon and produce pharmacological effect. In conclusion, Tat-CS-NPs as vehicles for colon-specific drug delivery may be an efficient approach to improve oral bioavailability of protein and peptide drugs.

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Recent Approaches in Insulin Delivery

Cited by 38 publications

References 54 publications

Needle-free injection of insulin powder: delivery efficiency and skin irritation assessment

Needle-free injection of insulin powder: delivery efficiency and skin irritation assessment

Hydrophobic ion pairing of an insulin-sodium deoxycholate complex for oral delivery of insulin

Modified nanoparticles with cell-penetrating peptide and amphipathic chitosan derivative for enhanced oral colon absorption of insulin: preparation and evaluation

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