Recent Applications of Quantum Dots in Pharmaceutical Analysis

Belal, Fathalla; Mabrouk, Mokhtar M.; Hammad, Sherin F.; Ahmed, Hytham M.; Barseem, Aya

doi:10.1007/s10895-023-03276-2

Cited by 10 publications

(3 citation statements)

References 249 publications

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“… 24,25 CDs are small carbon nanoparticles with dimensions below 10 nm. 26 Compared to traditional semiconductor quantum dots, CDs exhibit superior optical properties, excellent biocompatibility, low toxicity, and environmental friendliness. 27 These features make them highly promising materials for a variety of applications including sensing, bioimaging, photocatalysis, and optoelectronic devices.…”

Section: Introductionmentioning

confidence: 99%

“…Top-down methods involve breaking down carbon-based precursors like carbon nanotubes or graphite using electrochemical oxidation, laser ablation, arc discharge, or chemical oxidation. 26,28,29 Bottom-up methods build up CDs from molecular precursors using hydrothermal treatment, microwave synthesis, ultrasonic synthesis, or thermal decomposition. 30 Additional post-treatment steps like surface passivation are often utilized to enhance the CDs' photoluminescence.…”

Section: Introductionmentioning

confidence: 99%

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Cobalt-modulated dual emission carbon dots for ratiometric fluorescent vancomycin detection

Alhazzani,

Alanazi,

Mostafa

et al. 2024

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cobalt-modulated dual emission carbon dots for ratiometric fluorescent vancomycin detection

Alhazzani,

Alanazi,

Mostafa

et al. 2024

RSC Adv.

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“…Moreover, lower reaction temperatures can be used frequently to produce the same product in comparison with conventional heating techniques [4]. For the synthesis of CQDs using microwave method, citric acid and urea derivatives are the most common chemicals as carbon and nitrogen sources, respectively [5,6]. Also, sucrose and urea are sometimes used to synthesize nitrogendoped carbon quantum dots (N-CQDs) [7,8].…”

mentioning

confidence: 99%

Highly fluorescent nitrogen‐doped carbon quantum dots prepared using sucrose and urea: Green synthesis, characterization, and use for determination of torsemide in its tablets and plasma samples

Abo Zaid,

El‐Enany,

Mostafa

et al. 2024

Luminescence

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A simple and facile microwave‐assisted method was developed for the synthesis of highly fluorescent nitrogen‐doped carbon quantum dots (N‐CQDs) using sucrose and urea. The produced quantum dots exhibited a strong emission band at 376 nm after excitation at 216 nm with quantum yield of 0.57. The as‐prepared N‐CQDs were characterized using Fourier‐transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM) images, and ultraviolet‐visible (UV‐visible) spectra. The average particle size was 7.7 nm. It was found that torsemide (TRS) caused an obvious quenching of the fluorescent N‐CQDs; so, they were used for its spectrofluorometric estimation. An excellent linear correlation was found between the fluorescence quenching of N‐CQDs and the concentration of the drug in the range of 0.10 to 1.0 μg/mL with limit of quantitation (LOQ) of 0.08 μg/mL and limit of detection (LOD) of 0.027 μg/mL. The method was successfully applied for the assay of the drug in its commercial tablets and spiked human plasma samples, and the results obtained were satisfactory. Complex GAPI was used for greenness assessment of the analytical procedures and the pre‐analysis steps. Interference likely to be introduced from co‐administered drugs was also studied.

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Near‐Infrared Fluorescence of Novel Pyridinium−Cyclic Enolate Betaine Dyes π‐Expanded by Condensed Cyclic Thiophene Spacers

Suzuki,

Saikusa,

Maeda

et al. 2024

ChemPhotoChem

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Herein, we report the synthesis of new near‐infrared (NIR) fluorescent dyes based on the pyridinium–cyclic enolate betaine (PCB) skeleton. The formation of the electron‐donor–π–electron‐acceptor (D–π–A) type dye with the electron‐donating N,N‐diphenylamino group and the electron‐accepting PCB skeleton through a series of π‐spacers allowed us to achieve NIR fluorescence. Particularly, a dye with a thienylisothianaohthene spacer showed NIR fluorescence with a significant intensity (λPL = 822 nm, ΦPL = 0.19 in DMSO). Detailed experimental and theoretical analyses suggested that the structural relaxation to a planar quinoidal form in the S1 state would be critical for intense NIR fluorescence.

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Recent Applications of Quantum Dots in Pharmaceutical Analysis

Cited by 10 publications

References 249 publications

Cobalt-modulated dual emission carbon dots for ratiometric fluorescent vancomycin detection

Cobalt-modulated dual emission carbon dots for ratiometric fluorescent vancomycin detection

Highly fluorescent nitrogen‐doped carbon quantum dots prepared using sucrose and urea: Green synthesis, characterization, and use for determination of torsemide in its tablets and plasma samples

Near‐Infrared Fluorescence of Novel Pyridinium−Cyclic Enolate Betaine Dyes π‐Expanded by Condensed Cyclic Thiophene Spacers

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