Recent and prominent examples of nano- and microarchitectures as hemoglobin-based oxygen carriers

Jansman, Michelle Maria Theresia; Hosta‐Rigau, Leticia

doi:10.1016/j.cis.2018.08.006

Cited by 57 publications

(64 citation statements)

References 179 publications

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“…There they act as a nitric oxide (NO) scavenger . Since NO is an important vasodilator, NO scavenging results in vasoconstriction, the subsequent cardiovascular problems and increased mortality rates …”

Section: Introductionmentioning

confidence: 99%

Low‐Fouling Electrosprayed Hemoglobin Nanoparticles with Antioxidant Protection as Promising Oxygen Carriers

Liu

Jansman

Thulstrup

et al. 2019

Macromolecular Bioscience

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10. 1002/mabi.201900293. Despite all the attempts to create advanced hemoglobin (Hb)-based oxygen carriers (HBOCs) employing an encapsulation platform, major challenges including attaining a high Hb loading and long circulation times still need to be overcome. Herein, the fabrication, for the first time, of nanoparticles fully made of Hb (Hb-NPs) employing the electrospray technique is reported. The Hb-NPs are then coated by antioxidant and self-polymerized poly(dopamine) (PDA) to minimize the conversion of Hb into nonfunctional methemoglobin (metHb). The PDA shell is further functionalized with poly(ethylene glycol) (PEG) to achieve stealth properties. The results demonstrate that the asprepared Hb-NPs are hemo-and biocompatible while offering antioxidant protection and decreasing the formation of metHb. Additionally, decoration with PEG results in decreased protein adsorption onto the Hb-NPs surface, suggesting a prolonged retention time within the body. Finally, the Hb-NPs also preserve the reversible oxygen-binding and releasing properties of Hb. All in all, within this study, a novel HBOCs with high Hb content is fabricated and its potential as an artificial blood substitute is evaluated.

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Section: Introductionmentioning

confidence: 99%

Low‐Fouling Electrosprayed Hemoglobin Nanoparticles with Antioxidant Protection as Promising Oxygen Carriers

Liu

Jansman

Thulstrup

et al. 2019

Macromolecular Bioscience

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“…However, no HBOCs have been approved by FDA for oxygen delivery in clinical patients due to their inevitable internal problems. Basically, when hemoglobin (Hb) is separated from red blood cells (RBCs), reduced ferrous ion in molecular heme produces oxygen radical by autoxidation, which results in serious cell injury . Although chemical modification or binding antioxidant enzyme can alleviate production of reactive oxygen free radicals to some extent, the presence of heme is still a risk factor.…”

Section: Methodsmentioning

confidence: 99%

“…[23] So far, it has developed several kinds of HBOCs, including chemically modified hemoglobin and conjugation with some large, inert molecules (dextran or polyethylene glycol). [26] Although chemical modification or binding antioxidant enzyme can alleviate production of reactive oxygen free radicals to some extent, [27,28] the presence of heme is still a risk factor. Basically, when hemoglobin (Hb) is separated from red blood cells (RBCs), reduced ferrous ion in molecular heme produces oxygen radical by autoxidation, which results in serious cell injury.…”

Section: Doi: 101002/adtp201900031mentioning

confidence: 99%

“…Basically, when hemoglobin (Hb) is separated from red blood cells (RBCs), reduced ferrous ion in molecular heme produces oxygen radical by autoxidation, which results in serious cell injury. [26] Although chemical modification or binding antioxidant enzyme can alleviate production of reactive oxygen free radicals to some extent, [27,28] the presence of heme is still a risk factor. Furthermore, heme-containing hemoglobin tetramer tends to dissociate into constituent dimers that are easily removed from the circulation by renal filtration and may lead to tubule obstruction, nephrocyte oxidation injury, and impaired renal function.…”

Section: Doi: 101002/adtp201900031mentioning

confidence: 99%

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Artificial Red Blood Cells Constructed by Replacing Heme with Perfluorodecalin for Hypoxia‐Induced Radioresistance

Han

Yin

et al. 2019

Advanced Therapeutics

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Radioresistance, a serious problem during radiotherapy (RT) caused by hypoxia, results in tumor relapse. Hemoglobin-based oxygen carriers (HBOCs) which can deliver oxygen, offer a promising option to cancer patients with radioresistance. However, the potential autoxidative cytotoxicity and renal toxicity of heme in hemoglobin (Hb) hamper their clinical application. Thus, here, a nano red blood cell (nnRBC) is fabricated that replaces heme with perfluorodecalin (FDC), a hydrophobic, high oxygen carrying fluorocarbon, and coated with membranes of RBCs. For the first time, nnRBCs provide a new method for the delivery of FDC since it cannot be emulsified by any FDA approved emulsifiers. nnRBCs encapsulate FDC with 8000% (w/w) drug loading efficiency and show superior storage stability within seven days. After intravenous delivery, nnRBCs reverse tumor hypoxia effectively compared with RT treatment alone. Of note, the components of nnRBCs are all from organisms or safe substances that have been verified by human testing, which gives nnRBCs great potential to rapidly enter into clinical trials.Radiotherapy (RT), as an effective treatment for solid tumors, is utilized in more than 60% cancer patients at present. [1,2] However, radio resistance resulting in tumor relapse must be solved for urgent need. [3][4][5] Abundant clinical data suggest that threefold radioresistance occurs on cells in hypoxia condition than welloxygenated cells. [6,7] Mechanism in this effect may involve further damage of DNA based on the reaction between molecular oxygen and DNA radicals induced in RT. [4,5,8] More severely, tumor hypoxia not only promotes damaged DNA repaired, but also

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“…and different methods (e.g., chemical modification and molecules encapsulation) and materials (e.g., gelatin, dextran, dopamine, and polyurethane) have been used to generate these microcarriers, which have definitely contributed to the field of biomedicine. [19][20][21] However, most of these resultant oxygen microcarriers are with simple functions, since it is not feasible for them to deliver oxygen controllably and these microcarriers have few applications in tissue engineering. Thus, multifunctional microcarriers with controllable oxygen delivery are still anticipated for realizing tissue repair.…”

Section: Doi: 101002/smll201901254mentioning

confidence: 99%

Responsive Porous Microcarriers With Controllable Oxygen Delivery for Wound Healing

Liu

Zhao

et al. 2019

Small

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Microcarriers with oxygen‐delivering capacity have attracted increasing interest in the field of tissue regeneration. Here, a kind of molybdenum disulfide quantum dots (MoS2 QDs) integrated responsive porous microcarriers with controllable oxygen‐delivering ability for wound healing is presented. The specific gelatin methacryloyl (GelMa) porous microcarriers are derived from inverse opal microparticles which can be decorated with the oxygen‐carrying protein hemoglobin. Because of their characteristic porous structure, interconnected nanochannels, and excellent biocompatibility, the resultant microcarriers could carry oxygen extensively and provide support for tissue repair physically and biologically. Besides, since the typical photothermal effect of 2D materials and their derived 2D QDs, the inverse opal particles integrated with MoS2 QDs are imparted with photo‐responsive capacity, which makes them able to release oxygen photo‐controllably. It is demonstrated that the designed microcarriers can promote the repair of abdominal wall defects effectively with their multifunctional features. These remarkable properties point to the potential value of the microcarriers in wound healing and tissue engineering.

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Recent and prominent examples of nano- and microarchitectures as hemoglobin-based oxygen carriers

Cited by 57 publications

References 179 publications

Low‐Fouling Electrosprayed Hemoglobin Nanoparticles with Antioxidant Protection as Promising Oxygen Carriers

Low‐Fouling Electrosprayed Hemoglobin Nanoparticles with Antioxidant Protection as Promising Oxygen Carriers

Artificial Red Blood Cells Constructed by Replacing Heme with Perfluorodecalin for Hypoxia‐Induced Radioresistance

Responsive Porous Microcarriers With Controllable Oxygen Delivery for Wound Healing

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