Recent analytical approaches in quality control of traditional Chinese medicines—A review

Jiang, Yong; David, Bruno; Tu, Pengfei; Barbin, Y.

doi:10.1016/j.aca.2009.10.024

Cited by 423 publications

(285 citation statements)

References 168 publications

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“…Traditionally, the quality and safety control for TCMs is based on its organic compounds (Jiang, David, Tu, & Barbin, 2010). However, the inorganic compounds in TCMs also affect the safety level.…”

Section: Introductionmentioning

confidence: 99%

Multielements determination and metal transfer investigation in herb medicine Bupleuri Radix by inductively coupled plasma‐mass spectrometry

Luo

Ding

et al. 2018

Food Science & Nutrition

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Bupleuri Radix is a famous traditional Chinese medicine (TCM) and an important raw material in TCM patent prescriptions. It is widely used in several countries, including China, Japan, South Korea, and America. However, the impact of heavy metal transfer rules on TCMs remains unknown. In this study, a total of 45 paired original medicines (OMs), decoction pieces (DPs), and vinegar‐processed (VPs) samples were simultaneously determined via inductively coupled plasma‐mass spectrometry after a microwave digestion. The concentrations of the elements were shown at three levels: (a) Al and Fe at the mg/g level; (b) Pb, Cu, Ba, Mn, Cr, and Ni at the mg/kg level; (c) Co, As, Cd, and Hg at μg/kg level. It is worth noting that the Cu levels were found to exceed the maximum concentration set by Chinese legislation (20.0 mg/kg). In addition, Mn, Ni, and Cu levels were higher in samples from the Gansu province than those from other provinces. The accumulation of the heavy metals decreased in the order of OMs > DPs > VPs; this was especially true for the Al and Fe levels. Furthermore, the results indicate that decocting the samples may reduce the intake of heavy metals. The element transfer ratios for decoctions were under 50% compared to herbal medicines and decreased in the order of Co > As > Mn > Hg > other metals. Our study strongly suggests that long‐term and regular monitoring for heavy metals in the plant is necessary.

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Section: Introductionmentioning

confidence: 99%

Multielements determination and metal transfer investigation in herb medicine Bupleuri Radix by inductively coupled plasma‐mass spectrometry

Luo

Ding

et al. 2018

Food Science & Nutrition

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“…2,3 Liquid chromatography (LC) has been applied as a rapid and economic method for the determination of multi-component in TCMs. 4 Among the liquid chromatography analytical methods, high performance liquid chromatography (HPLC) is the most popular one, due to its easy operation, wide suitability and high accuracy for the qualitative and quantitative analysis of TCMs. [5][6][7] However, in practice, some factors, such as efficiency, selectivity and sensitivity have been found to affect the analysis of complicated systems with HPLC.…”

Section: Introductionmentioning

confidence: 99%

Study on the Mixed-Mode HPLC Separation of Shuang-Huang-Lian and Xue‑Bi‑Jing Injections Based on an Ionic Liquid Column

Yang¹,

Zhang²,

Zhang³

et al. 2018

J. Braz. Chem. Soc.

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Both Shuang-Huang-Lian and Xue-Bi-Jing injections are clinically proven efficient and low cost medicines. However, the studies of their chromatographic separation are limited. In this study, a column based on ionic liquid stationary phase was applied for the first time for the analysis of these two injections. For Shuang-Huang-Lian injection, U-shaped plots of retention factors vs. mobile phase constitutions were obtained. This unique kind of separation behavior allowed a flexible adjustment of retention by tuning the mobile phase constituents. Then acids group was analyzed with hydrophilic chromatography mode, while glycosides group was analyzed with reversed phase chromatography mode. Similarly, constituents in Xue-Bi-Jing injection were analyzed with mixed mode high performance liquid chromatography (HPLC). Higher, medium and lower polarity groups were analyzed with hydrophilic interaction, reversed phase and normal phase liquid chromatography modes, respectively. Results from this work provided valuable information for the separation of complicated systems such as traditional Chinese medicine injections.Keywords: ionic liquid stationary phase, mixed-mode chromatography, Shuang-Huang-Lian injection, Xue-Bi-Jing injection IntroductionThe formulations of traditional Chinese medicines (TCMs) are becoming increasingly popular worldwide, mainly because of their high efficiency and low cost. However, TCM formulations are usually based on a whole plant and/or combination of several herbs, which contain more than dozens to hundreds of components. 1 Therefore, in order to ensure both the safety and efficacy of TCM formulations, it is necessary to establish simple and effective methods to determine as many constituents as possible.2,3 Liquid chromatography (LC) has been applied as a rapid and economic method for the determination of multi-component in TCMs. 4 Among the liquid chromatography analytical methods, high performance liquid chromatography (HPLC) is the most popular one, due to its easy operation, wide suitability and high accuracy for the qualitative and quantitative analysis of TCMs. [5][6][7] However, in practice, some factors, such as efficiency, selectivity and sensitivity have been found to affect the analysis of complicated systems with HPLC. 8Chromatographic stationary phase is the core of HPLC system. Therefore, the development of novel stationary phases with high separation efficiency and excellent selectivity has always been the focus point of improving the separating ability of HPLC. Accordingly, in this work novel ionic liquid (IL) bonded stationary phase has been studied. IL is a kind of novel material composed of ions and at the same time remains in liquid state at a temperature below 100 °C.9 ILs have demonstrated the versatility and tuneability in separation science. 10 Many types of ILs were immobilized on a support like silica or monolith as stationary phases for liquid chromatography. 11,12 Due to the designable character of the IL molecule, multi interactions between the IL stationary phas...

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“…In the last few decades TCM has attracted considerable attention from pharmaceutical companies as a potential source for discovery of bioactive compounds [1]. This interest required an extensive development of analytical methods for characterization of the constituents of such herbal medicinal products, recent progress in the field being reviewed in [2]. The problem of taste of TCM is closely related to the acceptance of drugs by patients just as in the case of Western pharmaceutical products.…”

Section: Introductionmentioning

confidence: 99%

Exploring bitterness of traditional Chinese medicine samples by potentiometric electronic tongue and by capillary electrophoresis and liquid chromatography coupled to UV detection

Yaroshenko

Kirsanov

Карцова

et al. 2016

Talanta

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a b s t r a c tInstrumental bitterness assessment of traditional Chinese herbal medicine (TCM) preparations was addressed in this study. Three different approaches were evaluated, high-performance liquid chromatography coupled to UV detector (HPLC), capillary electrophoresis coupled to UV detector (CE) and a potentiometric multisensor system -electronic tongue (ET). Most studies involving HPLC and CE separations use these as selective instruments for quantification of individual substances. However we employed these techniques to provide chromatographic or electrophoretic sample profiles. These profiles are somewhat analogous to the profiles produced by the ET. Profiles from all instruments were then related to professional sensory panel evaluations using projections on latent structures (PLS) regression. It was found that all three methods allow for bitterness assessment in TCM samples in terms of human sensory panel with root mean squared errors of prediction ca. 0.9 within bitterness scale from 0 (no bitterness) to 6 (maximal bitterness).

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Recent analytical approaches in quality control of traditional Chinese medicines—A review

Cited by 423 publications

References 168 publications

Multielements determination and metal transfer investigation in herb medicine Bupleuri Radix by inductively coupled plasma‐mass spectrometry

Multielements determination and metal transfer investigation in herb medicine Bupleuri Radix by inductively coupled plasma‐mass spectrometry

Study on the Mixed-Mode HPLC Separation of Shuang-Huang-Lian and Xue‑Bi‑Jing Injections Based on an Ionic Liquid Column

Exploring bitterness of traditional Chinese medicine samples by potentiometric electronic tongue and by capillary electrophoresis and liquid chromatography coupled to UV detection

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