Recent Advances Towards the Inclusion of Flow Chemistry within the Undergraduate Practical Class Curriculum

Cranwell, Philippa B.

doi:10.1055/s-0040-1719539

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…The steady increase of applications highlighting improved syntheses is thereby paralleled by a growing appreciation of pitfalls and challenges [ 6 – 7 ] as well as solutions for their rectification that result from increasing knowledge and experience [ 8 ]. Pleasingly, recent years have also witnessed the expansion of flow chemistry in university curricula [ 9 ] although considerable efforts are still needed to provide future chemists with hands-on experience in modern synthesis technologies.…”

Section: Introductionmentioning

confidence: 99%

Coupling biocatalysis with high-energy flow reactions for the synthesis of carbamates and β-amino acid derivatives

Leslie

Moody

Smyth

et al. 2021

Beilstein J. Org. Chem.

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A continuous flow process is presented that couples a Curtius rearrangement step with a biocatalytic impurity tagging strategy to produce a series of valuable Cbz-carbamate products. Immobilized CALB was exploited as a robust hydrolase to transform residual benzyl alcohol into easily separable benzyl butyrate. The resulting telescoped flow process was effectively applied across a series of acid substrates rendering the desired carbamate structures in high yield and purity. The derivatization of these products via complementary flow-based Michael addition reactions furthermore demonstrated the creation of β-amino acid species. This strategy thus highlights the applicability of this work towards the creation of important chemical building blocks for the pharmaceutical and speciality chemical industries.

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