Recent advances on the synthesis and application of tetrahydro-γ-carbolines

Accessing pyrrolo[1,2-a]indole derivatives via visible-light-induced dearomatizative cyclization of indoles

“…Indole-fused polycyclic scaffolds represent one of the most important heterocyclic motifs, which exist in many natural products and bioactive compounds featuring unique bioactivities. Specifically, there are a number of bioactive molecules containing pyrrolo[1,2- a ]indole scaffolds 1 (Fig. 1).…”

A General Protocol toward Synthesis of 3-Methylindoles Using Acenaphthoimidazolyidene-Ligated Oxazoline Palladacycle

“…T he indole ring is among the most ubiquitous heterocycles in nature. − Particularly, an indole nucleus featuring a methyl at the 3-position is referred as a “privileged structure”, called 3-methylindole, which enables a high affinity toward binding to many receptors (Scheme a). − For well over a hundred years, efficient synthetic methods − and direct functionalization − via organo-, , electro-, , and photocatalysis − of indoles still remain the core object of focus for chemists. In comparison with Fischer indole synthesis, transition metal catalysis via Pd chemistry is emerging as a powerful synthetic strategy for indoles. ,,, However, a convenient straightforward access to 3-methylindoles has been somewhat neglected to date. − Jørgensen et al first presented a route to synthesize 3-substituted indoles from 2-bromoiodobenzenes and allylamines at 140 °C .…”