Recent advances on the development of plasmon-assisted biosensors for detection of C-reactive protein

Nagy-Simon, Timea; Hada, Alexandru-Milentie; Suarasan, Sorina; Potara, Monica

doi:10.1016/j.molstruc.2021.131178

Cited by 9 publications

(4 citation statements)

References 77 publications

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“…For example, nanomaterials such as gold or silver nanoaggregates, core-shell plasmonic bimetallic nanoparticles, hybrid plasmonic-magnetic nanoparticles were coupled with specific bioreceptors (mainly antibodies) and Raman reporters such as rhodamine-6G (R6G), nile blue A (NBA), malachite green isothiocyanate (MGITC), methylene blue (MB), 4-mercaptobenzoic acid (4-MBA), etc., for the selective and ultrasensitive detection of several cardiac biomarkers. Different plasmonic nanoplatforms were fabricated and optimized for high sensitivity for either the direct or indirect SERS detection of various cardiac biomarkers, including CRP [53], cTnI, B-type natriuretic peptide (BNP), CK-MB, Myo, NT-proBNP, neutrophil gelatinase-associated lipocalin (NGAL), glycogen phosphorylase isoenzyme BB (GPBB), neuropeptide Y (NPY) and heart-type fatty acid-binding protein (H-FABP). The following paragraphs discuss several successful SERS biosensors for CVD summarized in Table 3, with emphasis on the nanostructure designs proposed for efficient sensing.…”

Section: Sers Biosensors For Cardiac Biomarkersmentioning

confidence: 99%

Progress in the Optical Sensing of Cardiac Biomarkers

et al. 2023

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Biomarkers play key roles in the diagnosis, risk assessment, treatment and supervision of cardiovascular diseases (CVD). Optical biosensors and assays are valuable analytical tools answering the need for fast and reliable measurements of biomarker levels. This review presents a survey of recent literature with a focus on the past 5 years. The data indicate continuing trends towards multiplexed, simpler, cheaper, faster and innovative sensing while newer tendencies concern minimizing the sample volume or using alternative sampling matrices such as saliva for less invasive assays. Utilizing the enzyme-mimicking activity of nanomaterials gained ground in comparison to their more traditional roles as signaling probes, immobilization supports for biomolecules and for signal amplification. The growing use of aptamers as replacements for antibodies prompted emerging applications of DNA amplification and editing techniques. Optical biosensors and assays were tested with larger sets of clinical samples and compared with the current standard methods. The ambitious goals on the horizon for CVD testing include the discovery and determination of relevant biomarkers with the help of artificial intelligence, more stable specific recognition elements for biomarkers and fast, cheap readers and disposable tests to facilitate rapid testing at home. As the field is progressing at an impressive pace, the opportunities for biosensors in the optical sensing of CVD biomarkers remain significant.

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Section: Sers Biosensors For Cardiac Biomarkersmentioning

confidence: 99%

Progress in the Optical Sensing of Cardiac Biomarkers

et al. 2023

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“…LSPR has been responsible for an enhanced electromagnetic field, inducing surfaceenhanced spectroscopic technologies [87]. Several scientists are increasingly interested in plasmon resonance-based optical sensors, especially noble metal nanostructured materials such as Pt, Au, and Ag nanoparticles with various shapes and sizes, exhibiting plasmonic features that have been successfully used as a powerful analytic technique [6,88]. Here, these plasmonic nanostructures were practically employed as efficient transducers that convert changes in the spectral location of refractive index, thereby shifting the LSPR Other authors have successfully developed a novel Zn porphyrin MOF-based fluorescence sensor of bisphenol A detection using luminescence quenching.…”

Section: Localized Surface Plasmon Resonance Phenomenon-based Optical Sensor For Phenolic Compoundsmentioning

confidence: 99%

“…Optical sensors have been known as simple analytical techniques to demonstrate numerous advantages such as facile design and effective detection, leading to promising potential applications in environmental metal ion monitoring [5]. Recently, plasmonic nanomaterials [6] and 2D materials [7] have rapidly emerged as unique sensing platforms for varieties of engineering applications thanks to their specific features such as enhanced electrical, optical, and electrochemical signals.…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in Plasmonic Sensors of Phenol and Its Derivatives

Son

Kim

et al. 2021

Applied Sciences

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Many scientists are increasingly interested in on-site detection methods of phenol and its derivatives because these substances have been universally used as a significant raw material in the industrial manufacturing of various chemicals of antimicrobials, anti-inflammatory drugs, antioxidants, and so on. The contamination of phenolic compounds in the natural environment is a toxic response that induces harsh impacts on plants, animals, and human health. This mini-review updates recent developments and trends of novel plasmonic resonance nanomaterials, which are assisted by various optical sensors, including colorimetric, fluorescence, localized surface plasmon resonance (LSPR), and plasmon-enhanced Raman spectroscopy. These advanced and powerful analytical tools exhibit potential application for ultrahigh sensitivity, selectivity, and rapid detection of phenol and its derivatives. In this report, we mainly emphasize the recent progress and novel trends in the optical sensors of phenolic compounds. The applications of Raman technologies based on pure noble metals, hybrid nanomaterials, and metal–organic frameworks (MOFs) are presented, in which the remaining establishments and challenges are discussed and summarized to inspire the future improvement of scientific optical sensors into easy-to-operate effective platforms for the rapid and trace detection of phenol and its derivatives.

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“…One important requirement to achieve high accuracy is the capability to detect trace levels of such proteins. This motivates the search for highly sensitive methods, such as surface-enhanced resonance Raman scattering (SERRS) to detect the target molecule adsorbed on plasmonic metallic nanostructures [ 29 , 30 ]. SERRS has been used to detect trace level concentrations of neurotransmitters [ 31 ], proteins [ [32] , [33] , [34] ], pesticides [ [35] , [36] , [37] ], heavy metal ions [ 38 ], and cancer biomarkers [ 33 , 34 , 39 ].…”

Section: Introductionmentioning

confidence: 99%