Recent Advances on the Development of Synthetic Strategies to Access Dibenzoxepine Derivatives

Abstract

Dibenzoxepines have gained privileged status in medicinal chemistry and drug discovery due to their appearance in various natural products and life-saving drug molecules. Dibenzoxepine based molecules such as artocarpols, asenapine and pacharin possess a wide range of biological activities including anti-inflammatory, antidepressant, antihypertensive, antiestrogenic and insecticidal activities. Therefore, designing and developing new methodologies to access dibenzoxepine core becomes a paramount research topic for organic/medicinal chemists. Herein, we reviewed various synthetic methods to access dibenzoxepine derivatives. The total syntheses of dibenzoxepine-based natural products and biologically/medicinally important molecules have also been reviewed.