Recent advances on tea polyphenols

Kanwar, Jyoti; Mujtaba, Taskeen; Mohammad, Imthiyaz; Huo, Congde; Chan, Tak Hang; Dou, Q. Ping

doi:10.2741/363

Cited by 90 publications

(59 citation statements)

References 134 publications

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“…Green tea polyphenols have been extensively studied as cancer chemopreventive agents. The catechins are major consisted of (-)-epigallocatechin-3-gallate (EGCG), (-)-epigallocatechin (EGC), (-)-epicatechin-3-gallate (ECG), and (-)-epicatechin (EC), EGCG is the most abundant and active compound that can block cancer progression (Jankun et al, 1997;Kanwar et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Association Between Green Tea and Colorectal Cancer Risk: A Meta-analysis of 13 Case-control Studies

Wang

Zeng²,

Duan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: Experimental studies have suggested green tea to be a chemopreventive agent for colorectal cancer, and many studies have examined possible associations. However, the conclusions were inconsistent or even contradictory, so we performed a meta-analysis based on published case-control studies to explore if green tea is indeed a protective factor. Methods: PubMed was searched up to May 10 th , 2012 for relevant studies, and references of included studies were manually searched. Finally 13 eligible studies, involving 12,636 cases and 38,419 controls were identified. After data extraction, a meta-analysis was performed using CMA v2 software. Results: The results indicated there may be a weak but not statistically significant reduced risk of colorectal cancer with high dose of green tea intake (OR=0.95, 95% CI:0.81-1.11, p=0.490.69-0.98). This protective effect was also found in all subgroups, except in American and European populations. Sensitivity analysis indicated the result to be robust. Publication bias was not detected by either funnel plot or Egger tests. Conclusion: The results of this meta-analysis indicate a weak lower tendency for colorectal cancer development with green tea consumption, but available epidemiologic data are insufficient to conclude that green tea may protect against colorectal cancer in humans.

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Section: Introductionmentioning

confidence: 99%

Association Between Green Tea and Colorectal Cancer Risk: A Meta-analysis of 13 Case-control Studies

Wang

Zeng²,

Duan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…EGCG has been indicated to modulate multiple signaling pathways, including the phosphoinositide 3-kinase (PI3-K)/Akt and mitogen-activated protein kinase (MAPK) signaling pathways, which may enable it to exert its cancer chemopreventive and therapeutic effects (16,17).…”

Section: Introductionmentioning

confidence: 99%

(-)-Epigallocatechin‑3‑gallate inhibition of Epstein‑Barr virus spontaneous lytic infection involves downregulation of latent membrane protein 1

Liu

Tang

et al. 2017

Exp Ther Med

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Abstract. The Epstein-Barr virus (EBV) lytic cycle contributes to the development of EBV-associated diseases. EBV-encoded latent membrane protein 1 (LMP1) is key to EBV lytic replication, and our previous work indicated that epigallocatechin-3-gallate (EGCG) inhibited constitutive EBV lytic infection through the suppression of LMP1-activated phosphoinositide 3-kinase/Akt and mitogen-activated protein kinase kinase/extracellular signal-related protein kinase 1/2 signaling. The present study demonstrated that LMP1 in CNE-LMP1 constructed cells significantly induced the expression of the EBV lytic proteins BZLF1 (P<0.001) and BMRF1 (P<0.05) compared with CNE1 cells. Following treatment with a specific DNAzyme that targets LMP1, significantly reduced protein expression levels of BZLF1 and BMRF1 in EBV-associated epithelial carcinoma CNE1-LMP1 cells (P<0.001 and P<0.01, respectively) and lymphoma B95.8 cells (both P<0.01) were observed. Furthermore, EGCG significantly inhibited the mRNA and protein expression levels of LMP1 (P<0.05) in an apparent dose-dependent manner in CNE1-LMP1 and B95.8 cells. Thus, the present findings indicated that the molecular mechanism underlying EGCG inhibition of EBV lytic infection involves downregulation of LMP1. IntroductionEpstein-Barr virus (EBV) is a human herpes virus that infects over 90% of the human population worldwide (1). EBV is suggested to be an environmental factor associated with the development of several human malignancies, including nasopharyngeal carcinoma (NPC), Burkitt's lymphoma, Hodgkin's disease (HD), gastric cancer, natural killer/T-cell lymphoma, acquired immune deficiency syndrome-and transplantation-associated lymphoma (2,3), breast carcinoma, and hepatocellular carcinoma (4,5). EBV, as all other herpes viruses, may establish a latent or lytic infection in host cells (6). Notably, studies suggest that EBV reactivation into a lytic cycle may contribute to the pathogenesis of malignancies (7,8). EBV lytic infection in vivo has been identified by elevated antibody titers against EBV lytic antigens and by increased viral DNA load in the serum/plasma, and these observations correspond with advanced cancer stages, poor prognosis or tumor recurrence following therapy (9,10). Additionally, serological studies have indicated that EBV lytic infection may occur months or years prior to a clinical diagnosis of NPC, HD or Burkitt's lymphoma, which suggests EBV lytic infection may be a risk factor for cancer development (11-13).Green tea contains (-)-epigallocatechin-3-gallate (EGCG), which is reported to have antioxidant, antibacterial and antitumor effects (14,15). EGCG has been indicated to modulate multiple signaling pathways, including the phosphoinositide 3-kinase (PI3-K)/Akt and mitogen-activated protein kinase (MAPK) signaling pathways, which may enable it to exert its cancer chemopreventive and therapeutic effects (16,17).EBV encoded latent membrane protein 1 (LMP1), which is considered to have oncogenic properties, has been identified in 90% of patients with NPC...

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“…From the large volume of published papers on animal models, the overall conclusion is that most of the studies have reported cancer preventive activity of tea catechins against carcinogenesis at different organ sites with strong evidence (Yang et al, 2009;Kanwar et al, 2012). However, a few other studies argue that the cancer preventive effect of tea on the treatment group was not significantly different from that on the control group (Yang et al, 2009).…”

Section: Prevention Of Cancermentioning

confidence: 99%

“…Most of the experiments were conducted in tobacco carcinogen-treated mouse models with a few studies in rat and hamster models. Green tea polyphenols have been shown to inhibit the growth of human lung cancer cells in test tubes (Kanwar et al, 2012). When tea preparations were administered during the initiation, promotion, or progression stages of carcinogenesis in rats, the inhibitory activities of theaflavin and EGCG have also been demonstrated.…”

Section: Prevention Of Cancermentioning

confidence: 99%

Tea and human health: biomedical functions of tea active components and current issues

Chen

Zhi

2015

J. Zhejiang Univ. Sci. B

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Originating in China, tea and tea planting have spread throughout the world since the middle of the Tang dynasty. Now people from 160 countries in the world are accustomed to tea drinking. A brief history of tea's medicinal role in China and its spread to the world are introduced. The effectiveness of tea active components and tea drinking on major human diseases, including cancer, metabolic syndrome, cardiovascular disease, and neurodegenerative diseases, is discussed. Also presented are some related issues, such as the bioavailability of tea active components, the new formulations of tea polyphenols, and the safety for consumers of dietary supplements containing tea polyphenols.

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Recent advances on tea polyphenols

Cited by 90 publications

References 134 publications

Association Between Green Tea and Colorectal Cancer Risk: A Meta-analysis of 13 Case-control Studies

Association Between Green Tea and Colorectal Cancer Risk: A Meta-analysis of 13 Case-control Studies

(-)-Epigallocatechin‑3‑gallate inhibition of Epstein‑Barr virus spontaneous lytic infection involves downregulation of latent membrane protein 1

Tea and human health: biomedical functions of tea active components and current issues

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