Recent Advances on Surface-modified Biomaterials Promoting Selective Adhesion and Directional Migration of Cells

A bioinspired Janus polyurethane membrane for potential periodontal tissue regeneration

“…One is the adhesion area increased with such microtopography, and the other is this micro-pit pattern may be more conducive to cell attachment. 8,31,32 Comparatively, the PU-BDO and PU-BE membranes do not show this property because of the absence of the Janus two-sided microstructure and functional groups. In addition to the rBMSCs, the cell behavior of L929 cells on the membranes was also tested (Fig.…”

“…31 A special microscopic topology to mimic the extracellular matrix (ECM) is beneficial to the cell adhesion behavior from the 2D mode to 3D mode. 32 In addition, ridge, well, sphere, and honeycomb structures are verified to have the magical effects of regulating cell behavior and changing cell fate. 31,33 For example, Chen et al constructed fluted structures on membrane surfaces that significantly promoted the adhesion of cancer cells and mesenchymal stem cells.…”

Biomedical polymers: synthesis, properties, and applications

“…The biomedical polymers used for tissue repair and regeneration can be divided into two classifications: ex vivo and in situ. The in situ approach, also defined as endogenous regeneration, requires biochemical or biophysical factors in combination with self-adaptive and bioresponsive materials [408], which can modulate or respond to multiple cell behaviors such as directional cell migration [409,410], selective cell adhesion [411], extracellular signal pathways [412], and intracellular gene programming [413].…”

RGD Nanoarrays with Nanospacing Gradient Selectively Induce Orientation and Directed Migration of Endothelial and Smooth Muscle Cells

“…Cell migration is closely related to embryogenesis, wound healing, cancer invasion, and other physiological and pathological processes. , Signaling molecules may be used to induce cell migration along directional cues. , A gradient of a signal field can lead to symmetry breaking and guide cell behaviors. , In recent years, the introduction of some signals such as chemotaxis, galvanotaxis, topotaxis, and durotaxis , has offered the basic strategy to construct gradient biomaterials, which serve as models to study anisotropic cell behaviors in a precisely defined environment …”

“…3,4 A gradient of a signal field can lead to symmetry breaking and guide cell behaviors. 5,6 In recent years, the introduction of some signals such as chemotaxis, 7 galvanotaxis, 8 topotaxis, 9 and durotaxis 10,11 has offered the basic strategy to construct gradient biomaterials, which serve as models to study anisotropic cell behaviors in a precisely defined environment. 12 Cell−material interactions are particularly important in the fields of biomaterials, 13−15 cell biology, 16,17 and regenerative medicine.…”