Recent advances on porous interfaces for biomedical applications

Liang, Jing; Li, Bao; Wu, Lixin

doi:10.1039/d0sm00997k

Cited by 7 publications

(2 citation statements)

References 114 publications

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“…Creating controlled porosity on substrates is possible by various methods, such as photolithography and ion-track technology [84], the latter being already implemented to fabricate porous polycarbonate membranes, which are commercialized for cell culture applications [85]. On the other hand, self-assembly techniques such as water droplet-assisted methods [86] including breath figure [87] and phase separation methods [88] can still be considered as alternative to lithography techniques.…”

Section: Discussionmentioning

confidence: 99%

Nanoscale Topographies for Corneal Endothelial Regeneration

et al. 2021

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The corneal endothelium is the innermost layer of the cornea that selectively pumps ions and metabolites and regulates the hydration level of the cornea, ensuring its transparency. Trauma or disease affecting human corneal endothelial cells (hCECs) can result in major imbalances of such transport activity with consequent deterioration or loss of vision. Since tissue transplantation from deceased donors is only available to a fraction of patients worldwide, alternative solutions are urgently needed. Cell therapy approaches, in particular by attempting to expand primary culture of hCECs in vitro, aim to tackle this issue. However, existing cell culture protocols result in limited expansion of this cell type. Recent studies in this field have shown that topographical features with specific dimensions and shapes could improve the efficacy of hCEC expansion. Therefore, potential solutions to overcome the limitation of the conventional culture of hCECs may include recreating nanometer scale topographies (nanotopographies) that mimic essential biophysical cues present in their native environment. In this review, we summarize the current knowledge and understanding of the effect of substrate topographies on the response of hCECs. Moreover, we also review the latest developments for the nanofabrication of such bio-instructive cell substrates.

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Section: Discussionmentioning

confidence: 99%

Nanoscale Topographies for Corneal Endothelial Regeneration

et al. 2021

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“…17 Inspired by this natural phenomenon, a method called breath figure self-assembly has been proposed for the fabrication of highly ordered honeycomb polymer microstructures in the last 20 years. [18][19][20] Without using any instruments and moulds, but using coagulated waterdrops as an original template, a variety of honeycomb arrays with different sizes and configurations have been produced by changing the polymer structure used or the preparation conditions. However, in a typical breath figure mode, both the specified polymers and the high humidity environment are the primary factors necessary for obtaining an ordered structure, which restricts its widespread application.…”

Section: Introductionmentioning

confidence: 99%

The rapid and controllable fabrication of large-scale and highly ordered micro-honeycomb arrays induced by nonsolvent phase separation

et al. 2021

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Immobilization of Active Substances in Food Using Self‐Organized Patterned Porous Film via Breath Figure Approach

Zhang

Peng

et al. 2021

ChemistrySelect

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Micropattern of bioactive substances in food, such as functional protein and enzyme immobilization, play a crucial role in catalysis, proteomics, tissue engineering, nutrition transportation and biological detection. Currently, various techniques have been reported for the immobilization of bioactive substances on solid but the fabricated methods are often not facile and universal. In this study, we overcome these problems to localized capture ovalbumin (OVA) and trypsin (Try) efficiently by fabricating patterned porous film via simple breath figure approach. Upon optimization of preparation conditions, ordered honeycomb porous film were obtained. We confirmed the morphology and investigated thermostability and surface wettability of porous film. The immobilization of OVA and Try was confirmed by confocal laser scanning microscopy and SDS‐polyacrylamide gel electrophoresis, respectively. To our best knowledge, this work is the first report on patterning and trapping of food protein and enzyme via self‐organized patterned porous film. Our findings are essential for establishing a new convenient and efficient route to design food protein/enzyme‐trapped porous film materials, which opens a new sustainable way for food protein/enzyme immobilization and expected to used in the food industry, biological applications, and so on.

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Recent advances on porous interfaces for biomedical applications

Abstract: The recent achievements concerning porous structures are reviewed for the applications in biomedical-related systems due to their potential in the culture, proliferation, adhesion, and differentiation of cells, inhibition and separation of bacteria.

Cited by 7 publications

References 114 publications

Nanoscale Topographies for Corneal Endothelial Regeneration

Nanoscale Topographies for Corneal Endothelial Regeneration

The rapid and controllable fabrication of large-scale and highly ordered micro-honeycomb arrays induced by nonsolvent phase separation

Immobilization of Active Substances in Food Using Self‐Organized Patterned Porous Film via Breath Figure Approach

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