Recent advances on oxadiazole motifs: Synthesis, reactions and biological activities

Abstract

<p>1,3,4-oxadiazole derivatives have shown to have diverse and vast applications, from medicinal chemistry for the treatment and possible treatment of various ailments to its application in the industrial development when used as corrosion inhibitions and light emitting diodes. These diverse applications can be as a result of the numerous viable synthetic pathways illustrated in this review. 1,3,4-oxadiazoles can be synthesized in very high yields, using green approaches and having various life-changing applications. This review explores the various recent synthetic routes available for the development of 1,3,4-oxadiazoles and their biological activities.</p>

Untitled

“…Schiff bases prepared from the reaction of carbonyl group with primary amine in the carbonyl group reacts with a primary amine in the acids presence to create Schiff bases. Schiff bases, especially those with a heterocyclic moiety, such as 1,3,4-oxadiazole, have cytotoxic, antibacterial, and antifungal properties [5,6]. Diazetidine is one of the most important nitrogen-containing compounds, and it has become extremely important in medical and pharmaceutical applications such as antibacterial activity [7][8][9].…”

Synthesis, molecular docking study and anticancer activity of novel 1,3,4-oxadiazole derivatives as potential tubulin inhibitors

“…Fig. 1 shows the structures of a few therapeutically utilized medications that share the 1,3,4-oxadiazole scaffold [ 19 ].

Fig.

…”

Design, Synthesis, In Silico and In Vitro Studies for New Nitric Oxide-Releasing Indomethacin Derivatives with 1,3,4-Oxadiazole-2-thiol Scaffold

“…In nature, the oxadiazole scaffold has been reported to occur in quisqualic acid (from Quiqualis fructus, strong agonist of (AMPA)-subtype glutamate receptor) and phidianidines A and B (from primitive marine organisms, high cytotoxicity against tumor mammalian cell lines) [63,64].…”