Recent advances on macromolecular medicinal materials for radioprotection

Li, Yulin; Wu, Xinqi; Yang, Pei; Wang, Ziyu; Wang, Cheng; Hua, Daoben

doi:10.1016/j.jddst.2023.104224

Cited by 3 publications

(3 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8 Radiation protectants can prevent or treat radiation damage by scavenging ROS of radiation products, supplying hydrogen atoms, inducing hypoxia, and other ways, so the development of radiation protectants is of great significance. 9 Therapeutic radiation usually causes most of the damage by producing ROS. In order to resist ROS-mediated damage, the endogenous antioxidant defense system chelates and removes excessive ROS in cells.…”

Section: Radiation Protection Agentmentioning

confidence: 99%

“…Exposure to ionizing radiation can lead to molecular, cell, or even tissue damage, resulting in an increased rate of gene mutation, cell death, or tissue disorder . Radiation protectants can prevent or treat radiation damage by scavenging ROS of radiation products, supplying hydrogen atoms, inducing hypoxia, and other ways, so the development of radiation protectants is of great significance …”

Section: Radiation Protection Agentmentioning

confidence: 99%

See 1 more Smart Citation

Advances of Amifostine in Radiation Protection: Administration and Delivery

Ji,

Cui,

Zhou

et al. 2023

Mol. Pharmaceutics

Self Cite

View full text Add to dashboard Cite

Amifostine (AMF, also known as WR-2721) is the only approved broad-spectrum small-molecule radiation protection agent that can combat hematopoietic damage caused by ionizing radiation and is used as an antitumor adjuvant and cell protector in cancer chemotherapy and radiotherapy. Amifostine is usually injected intravenously before chemotherapy or radiotherapy and has been used in the treatment of head and neck cancer. However, the inconvenient intravenous administration and its toxic side effects such as hypotension have severely limited its further application in clinic. In order to reduce the toxic and side effects, scientists are trying to develop a variety of drug administration methods and are devoted to developing a wide application of amifostine in radiation protection. This paper reviews the research progress of amifostine for radiation protection in recent years, discusses its mechanism of action, clinical application, and other aspects, with focus on summarizing the most widely studied amifostine injection administration and drug delivery systems, and explored the correlation between various administrations and drug efficacies.

show abstract

Section: Radiation Protection Agentmentioning

confidence: 99%

Section: Radiation Protection Agentmentioning

confidence: 99%

Advances of Amifostine in Radiation Protection: Administration and Delivery

Ji,

Cui,

Zhou

et al. 2023

Mol. Pharmaceutics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Novel drug delivery systems rely heavily on polymer carrier materials, which play a critical role in promoting pharmaceutical formulation innovation, intelligent manufacturing, and drug development. There are various drug loading modes for polymer carriers, including covalent conjugation to form polymer-drug conjugates, polymer micelle encapsulated drugs, polymer vesicle encapsulated drugs, and drugs dispersed in polymer gels [325][326][327][328]. Polymer carriers possess noteworthy characteristics, such as precise biocompatibility, low toxicity and low antigenicity, controllable drug loading capacity and release behavior, targeted drug distribution to specific cells or organelles, improved drug efficacy, reduced side effects, and expanded use for chemical drugs, protein drugs, peptide drugs, and nucleic acid drugs [329].…”

Section: Polymer Carriersmentioning

confidence: 99%

Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines

Qiu,

Zhang,

et al. 2023

J Nanobiotechnol

View full text Add to dashboard Cite

Traditional Chinese Medicines (TCMs) have been used for centuries for the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due to their poor water solubility, low bioavailability, and potential toxicity. Nanocarriers, such as liposomes, polymeric nanoparticles, inorganic nanoparticles and organic/inorganic nanohybrids based on active constituents from TCMs have been extensively studied as a promising strategy to improve the delivery of active constituents from TCMs to achieve a higher therapeutic effect with fewer side effects compared to conventional formulations. This review summarizes the recent advances in nanocarrier-based delivery systems for various types of active constituents of TCMs, including terpenoids, polyphenols, alkaloids, flavonoids, and quinones, from different natural sources. This review covers the design and preparation of nanocarriers, their characterization, and in vitro/vivo evaluations. Additionally, this review highlights the challenges and opportunities in the field and suggests future directions for research. Nanocarrier-based delivery systems have shown great potential in improving the therapeutic efficacy of TCMs, and this review may serve as a comprehensive resource to researchers in this field. Graphical abstract

show abstract

Advanced Application of Polymer Nanocarriers in Delivery of Active Ingredients from Traditional Chinese Medicines

Zhai,

Niu,

et al. 2024

Molecules

View full text Add to dashboard Cite

Active ingredients from Traditional Chinese Medicines (TCMs) have been a cornerstone of healthcare for millennia, offering a rich source of bioactive compounds with therapeutic potential. However, the clinical application of TCMs is often limited by challenges such as poor solubility, low bioavailability, and variable pharmacokinetics. To address these issues, the development of advanced polymer nanocarriers has emerged as a promising strategy for the delivery of TCMs. This review focuses on the introduction of common active ingredients from TCMs and the recent advancements in the design and application of polymer nanocarriers for enhancing the efficacy and safety of TCMs. We begin by discussing the unique properties of TCMs and the inherent challenges associated with their delivery. We then delve into the types of polymeric nanocarriers, including polymer micelles, polymer vesicles, polymer hydrogels, and polymer drug conjugates, highlighting their application in the delivery of active ingredients from TCMs. The main body of the review presents a comprehensive analysis of the state-of-the-art nanocarrier systems and introduces the impact of these nanocarriers on the solubility, stability, and bioavailability of TCM components. On the basis of this, we provide an outlook on the future directions of polymer nanocarriers in TCM delivery. This review underscores the transformative potential of polymer nanocarriers in revolutionizing TCM delivery, offering a pathway to harness the full therapeutic potential of TCMs while ensuring safety and efficacy in a modern medical context.

show abstract

Recent advances on macromolecular medicinal materials for radioprotection

Cited by 3 publications

References 112 publications

Advances of Amifostine in Radiation Protection: Administration and Delivery

Advances of Amifostine in Radiation Protection: Administration and Delivery

Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines

Advanced Application of Polymer Nanocarriers in Delivery of Active Ingredients from Traditional Chinese Medicines

Contact Info

Product

Resources

About