Abstract:Spermatogonial stem cells (SSCs) are the most primitive spermatogonia in the testis. A balance between the self-renewal and differentiation of SSCs, strictly controlled in a special „niche‟ microenvironment in the seminiferous tubules (SSC niche), is essential to maintain normal spermatogenesis. Since the 1950s, many experimental methods, including histology, immunostaining, whole-mount analyses, and pulse-chase labeling, had been used in attempts to identify SSCs. Recent studies demonstrate that Aundiffseem t… Show more
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