Recent advances on anticancer activity of coumarin derivatives

Rawat, Anjali; Reddy, A. Vijaya Bhaskar

doi:10.1016/j.ejmcr.2022.100038

Cited by 51 publications

(24 citation statements)

References 78 publications

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“…Due to their unique nature and greater half-life, notably, warfarin is used more often compare to acenocoumarol. These results highlight a significant new development in the biological evaluation of coumarins and their derivatives, as well as medicinal chemistry [23][24][25][26][27][28][29][30]. As a current result, the coumarin heterocyclic ring system is widely used mostly in pharmaceutical industry to build a various functional groups present in the drug molecules.…”

Section: Introductionmentioning

confidence: 91%

Recent Methods for Synthesis of Coumarin Derivatives and Their New Applications

Sharma¹,

Dhayalan²,

Manikandan³

et al. 2023

Strategies for the Synthesis of Heterocycles and Their Applications

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Coumarin (2H-1-benzopyran-2-one) and its heterocyclic derivatives are widely used as lactone scaffolds used by innovative methods for the preparation of heterocyclic molecules. Nowadays, significant biological activities, as well as properties of unique nature coumarin derivatives, have played an important role in the development of novel drugs. This chapter entitles numerous methods of one-pot construction of coumarin derivatives, together with well-known name reactions and other type reactions as well, in the presence of various metal-based homogenous and heterogeneous catalyst system. Coumarin is one of the very important heterocycles and its analogs like natural product and pharmaceutically active drug molecules are extracted/isolated from a plants, animals, and microbes. Coumarin precursors have a wide range of biological activities Hence, the synthesis of coumarins and their heterocyclic analogs have become among the most interesting compound over the last many years in the growth of improved synthetic methodologies to form different types of functional groups that are present in coumarins derivatives. The synthesis of coumarins enabled by current approaches and their most recent bio-applications are discussed in this book chapter. Corresponding complex heterocycles-based coumarin analogs are produced from substituted alkyne substrates and other starting materials as well.

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Section: Introductionmentioning

confidence: 91%

Recent Methods for Synthesis of Coumarin Derivatives and Their New Applications

Sharma¹,

Dhayalan²,

Manikandan³

et al. 2023

Strategies for the Synthesis of Heterocycles and Their Applications

View full text Add to dashboard Cite

show abstract

“…The status of anticancer privileged heterocyclic scaffolds is not reserved for only nitrogen-based rings. Chromone [ 13 ] and coumarin [ 14 ] are examples of non-nitrogen structures that proved to be a useful template for the design of selective anticancer agents.…”

Section: Introductionmentioning

confidence: 99%

Quantitative and Qualitative Analysis of the Anti-Proliferative Potential of the Pyrazole Scaffold in the Design of Anticancer Agents

Nițulescu

2022

Molecules

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The current work presents an objective overview of the impact of one important heterocyclic structure, the pyrazole ring, in the development of anti-proliferative drugs. A set of 1551 pyrazole derivatives were extracted from the National Cancer Institute (NCI) database, together with their growth inhibition effects (GI%) on the NCI’s panel of 60 cancer cell lines. The structures of these derivatives were analyzed based on the compounds’ averages of GI% values across NCI-60 cell lines and the averages of the values for the outlier cells. The distribution and the architecture of the Bemis–Murcko skeletons were analyzed, highlighting the impact of certain scaffold structures on the anti-proliferative effect’s potency and selectivity. The drug-likeness, chemical reactivity and promiscuity risks of the compounds were predicted using AMDETlab. The pyrazole ring proved to be a versatile scaffold for the design of anticancer drugs if properly substituted and if connected with other cyclic structures. The 1,3-diphenyl-pyrazole emerged as a useful scaffold for potent and targeted anticancer candidates.

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“…(Rubiaceae), a tree found in west central Africa, and possess anti-HIV activity [ 60 , 61 , 62 , 63 ]. Even though several reviews referring the chemistry and biological aspects of coumarins and fused coumarins have been published to date, there are few reviews containing topics on the chemistry and biological activity of fused pyridocoumarins [ 11 , 42 , 64 , 65 , 66 , 67 ]. In this review, we present an overview of the advances described in the literature on the synthesis and biological evaluation of fused pyridocoumarins.…”

Section: Introductionmentioning

confidence: 99%

An Overview on the Synthesis of Fused Pyridocoumarins with Biological Interest

Douka¹,

Litinas²

2022

Molecules

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Pyridocoumarins are a class of synthetic and naturally occurring organic compounds with interesting biological activities. This review focuses on the synthetic strategies for the synthesis of pyridocoumarins and presents the biological properties of those compounds. The synthesis involves the formation of the pyridine ring, at first, from a coumarin derivative, such as aminocoumarins, hydroxycoumarins, or other coumarins. The formation of a pyranone moiety follows from an existing pyridine or piperidine or phenol derivative. For the above syntheses, [4 + 2] cycloaddition reactions, multi-component reactions (MCR), as well as metal-catalyzed reactions, are useful. Pyridocoumarins present anti-cancer, anti-HIV, antimalarial, analgesic, antidiabetic, antibacterial, antifungal, anti-inflammatory, and antioxidant activities.

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Recent advances on anticancer activity of coumarin derivatives

Cited by 51 publications

References 78 publications

Recent Methods for Synthesis of Coumarin Derivatives and Their New Applications

Recent Methods for Synthesis of Coumarin Derivatives and Their New Applications

Quantitative and Qualitative Analysis of the Anti-Proliferative Potential of the Pyrazole Scaffold in the Design of Anticancer Agents

An Overview on the Synthesis of Fused Pyridocoumarins with Biological Interest

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