Recent advances on anti-HIV chimeric antigen receptor-T-cell treatment to provide sustained HIV remission
Hang Su,
April Mueller,
Harris Goldstein
Abstract:Purpose of review
Successful sustained remission of HIV infection has been achieved after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation for treatment of leukemia in a small cohort of people living with HIV (PLWH). This breakthrough demonstrated that the goal of curing HIV was achievable. However, the high morbidity and mortality associated with bone marrow transplantation limits the routine application of this approach and provides a strong rationale for pursuing alternative strate… Show more
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