Recent advances of upconversion nanoparticles in theranostics and bioimaging applications

Rafique, Rafia; Kailasa, Suresh Kumar; Park, Tae Jung

doi:10.1016/j.trac.2019.115646

Cited by 68 publications

(34 citation statements)

References 100 publications

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“…Rare-earth-activated systems have been demonstrated to be the pillar of photonic technologies enabling a broad spectrum of crucial applications in strategic social and economic priorities [1][2][3][4][5]. Systems based on rare-earth-doped upconverters are largely employed in bioimaging, drug delivery, laser, lighting, photon management, environmental sensing, and nanothermometry [6][7][8][9][10][11][12][13][14][15]. Upconversion (UC) mechanism is a process of energy transfer from a sensitizer in a proper host matrix, which is excited under lowenergy radiation (usually near infrared, NIR), to an emitter that emits higher energy photons than the excitation ones.…”

Section: Introductionmentioning

confidence: 99%

Upconversion Luminescence of Silica–Calcia Nanoparticles Co-doped with Tm3+ and Yb3+ Ions

Halubek-Gluchowska

Szymański

Tran³

et al. 2021

Materials

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Looking for upconverting biocompatible nanoparticles, we have prepared by the sol–gel method, silica–calcia glass nanopowders doped with different concentration of Tm3+ and Yb3+ ions (Tm3+ from 0.15 mol% up to 0.5 mol% and Yb3+ from 1 mol% up to 4 mol%) and characterized their structure, morphology, and optical properties. X-ray diffraction patterns indicated an amorphous phase of the silica-based glass with partial crystallization of samples with a higher content of lanthanides ions. Transmission electron microscopy images showed that the average size of particles decreased with increasing lanthanides content. The upconversion (UC) emission spectra and fluorescence lifetimes were registered under near infrared excitation (980 nm) at room temperature to study the energy transfer between Yb3+ and Tm3+ at various active ions concentrations. Characteristic emission bands of Tm3+ ions in the range of 350 nm to 850 nm were observed. To understand the mechanism of Yb3+–Tm3+ UC energy transfer in the SiO2–CaO powders, the kinetics of luminescence decays were studied.

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Section: Introductionmentioning

confidence: 99%

Upconversion Luminescence of Silica–Calcia Nanoparticles Co-doped with Tm3+ and Yb3+ Ions

Halubek-Gluchowska

Szymański

Tran³

et al. 2021

Materials

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“…In the last decades, nanotechnology evolved to improve material properties focused on biomedical applications as antimicrobials [ 1 ], antiviral [ 2 ], drug delivery systems, treatment of cancer [ 3 ], and bioimaging [ 4 ], among others [ 5 , 6 ]. Nanomedicine and nanotoxicology are focused on determining the effectiveness and risk of nanomaterials used for specific biomedical and therapeutic applications.…”

Section: Introductionmentioning

confidence: 99%

New Protein-Coated Silver Nanoparticles: Characterization, Antitumor and Amoebicidal Activity, Antiproliferative Selectivity, Genotoxicity, and Biocompatibility Evaluation

et al. 2021

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Nanomaterials quickly evolve to produce safe and effective biomedical alternatives, mainly silver nanoparticles (AgNPs). The AgNPs’ antibacterial, antiviral, and antitumor properties convert them into a recurrent scaffold to produce new treatment options. This work reported the full characterization of a highly biocompatible protein-coated AgNPs formulation and their selective antitumor and amoebicidal activity. The protein-coated AgNPs formulation exhibits a half-inhibitory concentration (IC50) = 19.7 µM (2.3 µg/mL) that is almost 10 times more potent than carboplatin (first-line chemotherapeutic agent) to inhibit the proliferation of the highly aggressive human adenocarcinoma HCT-15. The main death pathway elicited by AgNPs on HCT-15 is apoptosis, which is probably stimulated by reactive oxygen species (ROS) overproduction on mitochondria. A concentration of 111 µM (600 µg/mL) of metallic silver contained in AgNPs produces neither cytotoxic nor genotoxic damage on human peripheral blood lymphocytes. Thus, the AgNPs formulation evaluated in this work improves both the antiproliferative potency on HCT-15 cultures and cytotoxic selectivity ten times more than carboplatin. A similar mechanism is suggested for the antiproliferative activity observed on HM1-IMSS trophozoites (IC50 = 69.2 µM; 7.4 µg/mL). There is no change in cell viability on mice primary cultures of brain, liver, spleen, and kidney exposed to an AgNPs concentration range from 5.5 µM to 5.5 mM (0.6 to 600 µg/mL). The lethal dose was determined following the OECD guideline 420 for Acute Oral Toxicity Assay, obtaining an LD50 = 2618 mg of Ag/Kg body weight. All mice survived the observational period; the histopathology and biochemical analysis show no differences compared with the negative control group. In summary, all results from toxicological evaluation suggest a Category 5 (practically nontoxic) of the Globally Harmonized System of Classification and Labelling of Chemicals for that protein-coated AgNPs after oral administration for a short period and urge the completion of its preclinical toxicological profile. These findings open new opportunities in the development of selective, safe, and effective AgNPs formulations for the treatment of cancer and parasitic diseases with a significant reduction of side effects.

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“…Narrow multicolor emission, exceptional photostability, and low cytotoxicity represent the properties that confer UCNP advantageous in multiplexing and long-term detection in biological settings. UCNP were found nontoxic according to a broad range of experiments in vitro and in vivo, although several studies have shown variation in their cytotoxicity depending on their surface modifications [ 7 , 8 , 9 ]. The modest UCNP’s conversion efficiency has been improved by introducing homogenous core/shell crystal structure and tunable crystallinity [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Controlled Formation of a Protein Corona Composed of Denatured BSA on Upconversion Nanoparticles Improves Their Colloidal Stability

et al. 2021

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In the natural fluidic environment of a biological system, nanoparticles swiftly adsorb plasma proteins on their surface forming a “protein corona”, which profoundly and often adversely affects their residence in the systemic circulation in vivo and their interaction with cells in vitro. It has been recognized that preformation of a protein corona under controlled conditions ameliorates the protein corona effects, including colloidal stability in serum solutions. We report on the investigation of the stabilizing effects of a denatured bovine serum albumin (dBSA) protein corona formed on the surface of upconversion nanoparticles (UCNPs). UCNPs were chosen as a nanoparticle model due to their unique photoluminescent properties suitable for background-free biological imaging and sensing. UCNP surface was modified with nitrosonium tetrafluoroborate (NOBF4) to render it hydrophilic. UCNP-NOBF4 nanoparticles were incubated in dBSA solution to form a dBSA corona followed up by lyophilization. As produced dBSA-UCNP-NOBF4 demonstrated high photoluminescence brightness, sustained colloidal stability after long-term storage and the reduced level of serum protein surface adsorption. These results show promise of dBSA-based nanoparticle pretreatment to improve the amiability to biological environments towards theranostic applications.

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Recent advances of upconversion nanoparticles in theranostics and bioimaging applications

Cited by 68 publications

References 100 publications

Upconversion Luminescence of Silica–Calcia Nanoparticles Co-doped with Tm3+ and Yb3+ Ions

Upconversion Luminescence of Silica–Calcia Nanoparticles Co-doped with Tm3+ and Yb3+ Ions

New Protein-Coated Silver Nanoparticles: Characterization, Antitumor and Amoebicidal Activity, Antiproliferative Selectivity, Genotoxicity, and Biocompatibility Evaluation

Controlled Formation of a Protein Corona Composed of Denatured BSA on Upconversion Nanoparticles Improves Their Colloidal Stability

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