Recent Advances of Total Syntheses of Diterpenoids Starting from Carvone

Abstract

This review focuses on total syntheses of diterpenoids starting from carvone (1) since 2006 in the alphabetical order of compound names.

Introduction of Chiral Centers to α- and/or β-Positions of Carbonyl Groups by Biocatalytic Asymmetric Reduction of α,β-Unsaturated Carbonyl Compounds

“…Dihydrocarvone ( 1 ) is a very versatile chiral building block for natural product syntheses, because it has a six-membered ring, two chiral centers and two functional groups for further transformations. 46 Chemo- and diastereoselective bioreductions of the enone moiety of carvone are listed in entries 27∼32, in which both enantiomers were obtained. Although selective reduction of an enone moiety in the presence of either a non-conjugated double bond or ketone is usually carried out by an electron transfer process to avoid over-reduction of such substituents, stereoselectivity of the process is not always satisfactory.…”