Recent Advances of Thiazole Hybrids in Biological Applications

Gümüş, Mehmet; Yakan, Mehmet; Koca, İrfan

doi:10.4155/fmc-2018-0196

Cited by 82 publications

(38 citation statements)

References 78 publications

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“…Nowadays, particular attention is given to hybrid molecules containing a thiazole nucleus in combination with other pharmacophore features. Numerous hybrid molecules of thiazole combined with different heterocycles, such as thiophene, pyrazole, triazole, 1,3,4-oxadiazole, pyridine, 1,4-dihydropyridine, indole, quinoline, pyrimidine, pyrazine, triazine, and pyrazoline, were designed, synthesized, and evaluated as antimicrobial agents [48][49][50]. Moreover, novel hydrazones and Schiff bases bearing a thiazole scaffold have demonstrated good antimicrobial activity [51,52].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives

et al. 2021

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Thiazole, a five-membered heteroaromatic ring, is an important scaffold of a large number of synthetic compounds. Its diverse pharmacological activity is reflected in many clinically approved thiazole-containing molecules, with an extensive range of biological activities, such as antibacterial, antifungal, antiviral, antihelmintic, antitumor, and anti-inflammatory effects. Due to its significance in the field of medicinal chemistry, numerous biologically active thiazole and bisthiazole derivatives have been reported in the scientific literature. The current review provides an overview of different methods for the synthesis of thiazole and bisthiazole derivatives and describes various compounds bearing a thiazole and bisthiazole moiety possessing antibacterial, antifungal, antiprotozoal, and antitumor activity, encouraging further research on the discovery of thiazole-containing drugs.

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Section: Antimicrobial Activitymentioning

confidence: 99%

An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives

et al. 2021

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“…Thiazoles are versatile compounds found in numerous natural products such as the microbial secondary metabolites epothilones A and B [ 100 ] and the cyclic peptides urukthapelstatin A [ 101 ], aerucyclamides A–D [ 102 ], and hexamollamide [ 103 ], as well as in commercial drugs, for example the antiretroviral ritonavir [ 104 ], the antifungal abafungin [ 105 ], and the antibiotic sulfathiazole [ 106 ]. Since thiazoles exhibit noteworthy cytotoxic activities [ 107 , 108 ], the development of their pyrazoline conjugates [ 109 ] seems a reasonable and promising strategy for potential anticancer agents.…”

Section: 2-pyrazolinesmentioning

confidence: 99%

Pyrazoline Hybrids as Promising Anticancer Agents: An Up-to-Date Overview

Matiadis

Sagnou

2020

IJMS

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Pyrazolines are five-membered heterocycles possessing two adjacent nitrogens. They have attracted significant attention from organic and medicinal chemists due to their potent biological activities and the numerous possibilities for structural diversification. In the last decade, they have been intensively studied as targets for potential anticancer therapeutics, producing a steady yearly rise in the number of published research articles. Many pyrazoline derivatives have shown remarkable cytotoxic activities in the form of heterocyclic or non-heterocyclic based hybrids, such as with coumarins, triazoles, and steroids. The enormous amount of related literature in the last 5 years prompted us to collect all these published data from screening against cancer cell lines, or protein targets like EGFR and structure activity relationship studies. Therefore, in the present review, a comprehensive account of the compounds containing the pyrazoline nucleus will be provided. The chemical groups and the structural modifications responsible for the activity will be highlighted. Moreover, emphasis will be given on recent examples from the literature and on the work of research groups that have played a key role in the development of this field.

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“…As the aforesaid S-containing heterocycles are in the limelight, reviews encompassing the applicability of individual templates have been published till date. [19][20][21][22][23][24][25][26][27][28][29] However, few reviews have been published covering a group of S-containing heterocycles on a single platform. Wang et al, 17 concentrated more specifically on the development of natural products possessing sulfur heteroatom.…”

Section: Introductionmentioning

confidence: 99%

Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update

Laxmikeshav

Kumari

Shankaraiah

2021

Medicinal Research Reviews

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This review article proposes a comprehensive report of the design strategies engaged in the development of various sulfur-bearing cytotoxic agents. The outcomes of various studies depict that the sulfur heterocyclic framework is a fundamental structure in diverse synthetic analogs representing a myriad scope of therapeutic activities. A number of five-, six-and seven-membered sulfur-containing heterocyclic scaffolds, such as thiazoles, thiadiazoles, thiazolidinediones, thiophenes, thiopyrans, benzothiazoles, benzothiophenes, thienopyrimidines, simple and modified phenothiazines, and thiazepines have been discussed. The subsequent studies of the derivatives unveiled their cytotoxic effects through multiple mechanisms (viz. inhibition of tyrosine kinases, topoisomerase I and II, tubulin, COX, DNA synthesis, and PI3K/Akt and Raf/MEK/ERK signaling pathways), and several others. Thus, our concise illustration explains the design strategy and anticancer potential of these five-and six-membered sulfur-containing heterocyclic molecules along with a brief outline on seven-membered sulfur heterocycles. The thorough assessment of antiproliferative activities with the reference drug allows a proficient assessment of the structure-activity relationships (SARs) of the diversely synthesized molecules of the series.

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Recent Advances of Thiazole Hybrids in Biological Applications

Cited by 82 publications

References 78 publications

An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives

An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives

Pyrazoline Hybrids as Promising Anticancer Agents: An Up-to-Date Overview

Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update

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