Recent advances of superparamagnetic iron oxide nanoparticles and its applications in neuroscience under external magnetic field

Yang, Quyang; Li, Yue; Zhao, Xiansheng; Zhang, Jin; Cheng, Xian; Zhu, Nianyong

doi:10.1007/s13204-023-02803-8

Cited by 3 publications

(2 citation statements)

References 127 publications

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“…Thus, such nanoparticles typically require some form of functionalization to increase biocompatibility, decrease toxicity and improve properties such as stability and dispersity [8,11,12]. A current strategy relies on the use of biocompatible coating agents, containing an organic and/or inorganic material, to improve NPs stability and make them more versatile [12,13]. A dextran vs polyethylene glycol (PEG) coating study has been reported, highlighting the effect of the nature of the organic coating polymer on the magnetization performance of SPIONs.…”

Section: Introductionmentioning

confidence: 99%

Influence of SPIONs Surface Coating on Magnetic Properties and Theranostic Profile

Ferreira-Filho,

Morais,

Vieira

et al. 2024

Preprint

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This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction-precipitation (MR/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment of coating’s influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated by a detailed characterization analysis. To assess their efficacy in imaging and therapy, relaxivity and hyperthermia experiments were performed, respectively. The results revealed that both synthetic methods lead to SPIONs with similar average, 9 nm. Mössbauer spectroscopy indicated that samples obtained from MR/P consist of approximately 11-13% of Fe present in magnetite, while samples obtained from MpH have higher content, of 33%-45%. Despite coating and functionalization, all samples exhibited superparamagnetic behavior at room temperature. Hyperthermia experiments showed increased SAR values with higher magnetic field intensity and frequency. Moreover, the relaxivity studies suggested potential dual T1/T2 contrast agent capabilities for the coated SPpH-Dx-Au-Gd sample, thus demonstrating its potential in cancer diagnosis.

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Section: Introductionmentioning

confidence: 99%

Influence of SPIONs Surface Coating on Magnetic Properties and Theranostic Profile

Ferreira-Filho,

Morais,

Vieira

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Superparamagnetic iron oxide nanoparticles (SPIONs) below 10 nm have good superparamagnetism, excellent magnetic field response, and have been widely used in biomedical applications such as magnetothermia, MRI, bioseparation, catalysis, etc. [ 14 ]. SPIONs have good dispersibility and biocompatibility after surface treatment.…”

Section: Introductionmentioning

confidence: 99%

Advancing the Frontiers of Neuroelectrodes: A Paradigm Shift towards Enhanced Biocompatibility and Electrochemical Performance

Wang,

Liu,

Zhang

et al. 2024

Polymers

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The aim of this study is the fabrication of unprecedented neuroelectrodes, replete with exceptional biological and electrical attributes. Commencing with the synthesis of polyethylene glycol and polyethyleneimine-modified iron oxide nanoparticles, the grafting of Dimyristoyl phosphatidylcholine was embarked upon to generate DMPC-SPION nanoparticles. Subsequently, the deposition of DMPC-SPIONs onto a nickel–chromium alloy electrode facilitated the inception of an innovative neuroelectrode–DMPC-SPION. A meticulous characterization of DMPC-SPIONs ensued, encompassing zeta potential, infrared spectroscopy, X-ray photoelectron spectroscopy, and X-ray diffraction analyses. Evaluations pertaining to hemolysis and cytotoxicity were conducted to ascertain the biocompatibility and biosafety of DMPC-SPIONs. Ultimately, a comprehensive assessment of the biocompatibility, electrochemical properties, and electrophysiological signal acquisition capabilities of DMPC-SPION neuroelectrodes was undertaken. These findings conclusively affirm the exemplary biocompatibility, electrochemical capabilities, and outstanding capability in recording electrical signals of DMPC-SPION neuroelectrodes, with an astounding 91.4% augmentation in electrode charge and a noteworthy 13% decline in impedance, with peak potentials reaching as high as 171 μV and an impressive signal-to-noise ratio of 15.92. Intriguingly, the novel DMPC-SPION neuroelectrodes herald an innovative pathway towards injury repair as well as the diagnosis and treatment of neurological disorders.

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Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile

Ferreira-Filho,

Morais,

Vieira

et al. 2024

Molecules

View full text Add to dashboard Cite

This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction–precipitation (MR/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment of the coating’s influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated by a detailed characterization analysis. To assess their efficacy in imaging and therapy, relaxivity and hyperthermia experiments were performed, respectively. The results revealed that both synthetic methods lead to SPIONs with similar average size, 9 nm. Mössbauer spectroscopy indicated that samples obtained from MR/P consist of approximately 11–13% of Fe present in magnetite, while samples obtained from MpH have higher contents of 33–45%. Despite coating and functionalization, all samples exhibited superparamagnetic behavior at room temperature. Hyperthermia experiments showed increased SAR values with higher magnetic field intensity and frequency. Moreover, the relaxivity studies suggested potential dual T1/T2 contrast agent capabilities for the coated SPpH-Dx-Au-Gd sample, thus demonstrating its potential in cancer diagnosis.

show abstract

Recent advances of superparamagnetic iron oxide nanoparticles and its applications in neuroscience under external magnetic field

Cited by 3 publications

References 127 publications

Influence of SPIONs Surface Coating on Magnetic Properties and Theranostic Profile

Influence of SPIONs Surface Coating on Magnetic Properties and Theranostic Profile

Advancing the Frontiers of Neuroelectrodes: A Paradigm Shift towards Enhanced Biocompatibility and Electrochemical Performance

Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile

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