Recent advances of microneedles used towards stimuli-responsive drug delivery, disease theranostics, and bioinspired applications

Yang, Jingbo; Zhang, Haoxiang; Hu, Tianli; Xu, Chen; Jiang, Lelun; Zhang, Yu Shrike; Xie, Maobin

doi:10.1016/j.cej.2021.130561

Cited by 69 publications

(42 citation statements)

References 125 publications

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“…MNs are microscopic projections that disrupt the top layer of the skin in a non-invasive manner, creating micron-sized channels ranging in height from 25 to 2000 µm that allow drugs to reach the epidermis or upper dermis directly [283,286,289]. MNs have facilitated the transdermal delivery of not only low-molecular weight drugs [290,291] but also hydrophilic molecules [292,293], peptides and proteins [294][295][296][297], cosmeceuticals [298][299][300], microparticles [301,302], NEs [303], vaccines [304], and nanoparticles [285,305].…”

Section: Mechanical Approachesmentioning

confidence: 99%

Beneath the Skin: A Review of Current Trends and Future Prospects of Transdermal Drug Delivery Systems

et al. 2022

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The ideal drug delivery system has a bioavailability comparable to parenteral dosage forms but is as convenient and easy to use for the patient as oral solid dosage forms. In recent years, there has been increased interest in transdermal drug delivery (TDD) as a non-invasive delivery approach that is generally regarded as being easy to administer to more vulnerable age groups, such as paediatric and geriatric patients, while avoiding certain bioavailability concerns that arise from oral drug delivery due to poor absorbability and metabolism concerns. However, despite its many merits, TDD remains restricted to a select few drugs. The physiology of the skin poses a barrier against the feasible delivery of many drugs, limiting its applicability to only those drugs that possess physicochemical properties allowing them to be successfully delivered transdermally. Several techniques have been developed to enhance the transdermal permeability of drugs. Both chemical (e.g., thermal and mechanical) and passive (vesicle, nanoparticle, nanoemulsion, solid dispersion, and nanocrystal) techniques have been investigated to enhance the permeability of drug substances across the skin. Furthermore, hybrid approaches combining chemical penetration enhancement technologies with physical technologies are being intensively researched to improve the skin permeation of drug substances. This review aims to summarize recent trends in TDD approaches and discuss the merits and drawbacks of the various chemical, physical, and hybrid approaches currently being investigated for improving drug permeability across the skin.

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Section: Mechanical Approachesmentioning

confidence: 99%

Beneath the Skin: A Review of Current Trends and Future Prospects of Transdermal Drug Delivery Systems

et al. 2022

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“…In recent years, emerging porous microneedles were proved to be another solution for transdermal controlled release, with relatively facile fabrication, as shown in Fig. 9 b [ 201 – 203 ]. Specific physical forms were developed for unique applications as well, such as integrating soluble microneedle tips and bubble structure into a separatable microneedles (Fig.…”

Section: Semi-implantable Device For In Vivo Applicationsmentioning

confidence: 99%

“…9 a Transdermal drug delivery strategies using microneedles: (A) Various types of microneedles apply to the skin, and (B) corresponding methods used for drug delivery [ 200 ]. b Drug delivery strategy (left column) and SEM images (right column) of porous microneedles [ 201 , 202 ]. c–f Micrographs of representative novel physical forms of microneedles, including c rapidly separable microneedles (scale bar: 500 μm) [ 204 ].…”

Section: Semi-implantable Device For In Vivo Applicationsmentioning

confidence: 99%

Semi-Implantable Bioelectronics

et al. 2022

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Developing techniques to effectively and real-time monitor and regulate the interior environment of biological objects is significantly important for many biomedical engineering and scientific applications, including drug delivery, electrophysiological recording and regulation of intracellular activities. Semi-implantable bioelectronics is currently a hot spot in biomedical engineering research area, because it not only meets the increasing technical demands for precise detection or regulation of biological activities, but also provides a desirable platform for externally incorporating complex functionalities and electronic integration. Although there is less definition and summary to distinguish it from the well-reviewed non-invasive bioelectronics and fully implantable bioelectronics, semi-implantable bioelectronics have emerged as highly unique technology to boost the development of biochips and smart wearable device. Here, we reviewed the recent progress in this field and raised the concept of “Semi-implantable bioelectronics”, summarizing the principle and strategies of semi-implantable device for cell applications and in vivo applications, discussing the typical methodologies to access to intracellular environment or in vivo environment, biosafety aspects and typical applications. This review is meaningful for understanding in-depth the design principles, materials fabrication techniques, device integration processes, cell/tissue penetration methodologies, biosafety aspects, and applications strategies that are essential to the development of future minimally invasive bioelectronics.

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“…Promisingly, with the promotion of advanced micro-/nano-manufacturing technologies, such as micro-/nanoprocessing and laser microprocessing, cutting-edge painless transdermal technology based on microneedle (MN) arrays is gradually emerging. The length range of MN is usually 500-800 µm, which can just penetrate the stratum corneum of the skin and touch the dermis without reaching the blood vessels or nerves inside the dermis [23,24]. The minimally invasive characteristics of MNs can avoid not only the pain caused by transdermal behavior, but also tissue inflammation and fibrosis caused by tissue trauma [25], as shown in Fig.…”

Section: Introductionmentioning

confidence: 99%