Recent Advances of Manganese-Based Hybrid Nanomaterials for Cancer Precision Medicine

Liu, Xiaoman; Rong, Pengfei

doi:10.3389/fonc.2021.707618

Cited by 7 publications

(4 citation statements)

References 89 publications

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“…biocompatibility, high surface area, redox activity, stimuliresponsive, and tunable surface [121,165,166]. The Mn oxides are used in drug delivery in different forms like MnO 2 [167], MnO [168], Mn 2 O 3 [169], Mn 3 O 4 [34], and Mn-based composites [170,170]. Mn NP is used in different structures like rods [171], spheres [166], wires [172], sheets [173], platelets [174], mesoporous [166], hollow [175], etc.…”

Section: Medical Applicationsmentioning

confidence: 99%

Review on Medical Applications of Manganese Oxide (Mn2+, Mn3+, and Mn4+) Magnetic Nanoparticles

Manavalan,

Enoch,

Volegov

et al. 2024

Journal of Nanomaterials

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Apart from our imagination, the nanotechnology industry is rapidly growing and promises that the substantial changes that will have significant economic and scientific impacts be applicable to a wide range of areas, such as aerospace engineering, nanoelectronics, environmental remediation, and medical healthcare. In the medical field, magnetic materials play vital roles such as magnetic resonance imaging (MRI), hyperthermia, and magnetic drug delivery. Among them, manganese oxide garnered great interest in biomedical applications due to its different oxidation states (Mn2+, Mn3+, and Mn4+). Manganese oxide nanostructures are widely explored for medical applications due to their availability, diverse morphologies, and tunable magnetic properties. In this review, cogent contributions of manganese oxides in medical applications are summarized. The crystalline structure and oxidation states of Mn oxides are highlighted. The synthesis approaches of Mn-based nanoparticles are outlined. The important medical applications of manganese-based nanoparticles like magnetic hyperthermia, MRI, and drug delivery are summarized. This review is conducted to cover the future impact of MnOx in diagnostic and therapeutic applications.

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Section: Medical Applicationsmentioning

confidence: 99%

Review on Medical Applications of Manganese Oxide (Mn2+, Mn3+, and Mn4+) Magnetic Nanoparticles

Manavalan,

Enoch,

Volegov

et al. 2024

Journal of Nanomaterials

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“…The development of multifunctional nanoagents that can actualize a combination of PDT or PTT with chemotherapy and immunotherapy within the same platform, offers great promise for treatment of TNBC [13][14][15]. There have been several recent studies exploring this at in vitro and in vivo scale with particular focus on transition metal-based oxides and sulfides [16][17][18]. Transition metal-based oxides and sulfides offer the advantages of high NIR absorption, good photothermal conversion efficiency (PCE) and potential for chemodynamic therapy (CDT) based on Fenton and Fenton like reactions [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Tumor targeted nanohybrid for dual stimuli responsive and NIR amplified photothermal/photo-induced thermodynamic/chemodynamic combination therapy

Mehrotra,

Pal

2024

Biomed. Mater.

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The combination of photodynamic (PDT) and chemodynamic therapy (CDT) for cancer treatment has gathered a lot of attention in recent years. However, its efficacy is severely limited by elevated levels of hypoxia and glutathione (GSH) in the tumor microenvironment (TME). Multifunctional nanoparticles that can help remodel the TME while facilitating PDT/CDT combination therapy are the need of the hour. To this effect, we have developed O2 self-supplying, free radical generating nanohybrids that exhibit NIR triggered photothermal (PTT)/photo-induced thermodynamic (P-TDT) and chemodynamic therapy for efficient breast cancer treatment. The surface of nanohybrids has been further modified by biointerfacing with cancer cell membrane. The biomimetic nanohybrids have been comprehensively characterized and found to exhibit high AIPH loading, glutathione depletion, oxygen self-supply with tumor microenvironment responsive AIPH release. Biological activity assays demonstrate efficient cellular uptake with homotypic targeting, excellent hemo- and cytocompatibility as well as high intracellular reactive oxygen species generation with synergistic cytotoxicity against tumor cells. The multifunctional nanohybrid proposed in the present study provides an attractive strategy for achieving NIR responsive, tumor targeted PTT/P-TDT/CDT combination therapy for breast cancer treatment.

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“…Thanks to their extraordinary functions, Mn-based nanomaterials have sparked a growing interest in tumor immunotherapy. Although some reviews have systematically summarized the synthesis, properties, and theranostic applications of Mn-based nanomaterials, [35][36][37][38] there is a lack of systematical review on Mn-based tumor immunotherapy. Thus, in this review, we focus on the most recent progress of Mn-based nanoplatforms in tumor immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

Manganese‐Based Tumor Immunotherapy

Zhang

Cai

2023

Advanced Materials

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As an essential micronutrient, manganese (Mn) participates in various physiological processes and plays important roles in host immune system, hematopoiesis, endocrine function, and oxidative stress regulation. Mn‐based nanoparticles are considered to be biocompatible and show versatile applications in nanomedicine, in particular utilized in tumor immunotherapy in the following ways: 1) acting as a biocompatible nanocarrier to deliver immunotherapeutic agents for tumor immunotherapy; 2) serving as an adjuvant to regulate tumor immune microenvironment and enhance immunotherapy; 3) activating host's immune system through the cGAS‐STING pathway to trigger tumor immunotherapy; 4) real‐time monitoring tumor immunotherapy effect by magnetic resonance imaging (MRI) since Mn2+ ions are ideal MRI contrast agent which can significantly enhance the T1‐weighted MRI signal after binding to proteins. This comprehensive review focuses on the most recent progress of Mn‐based nanoplatforms in tumor immunotherapy. The characteristics of Mn are first discussed to guide the design of Mn‐based multifunctional nanoplatforms. Then the biomedical applications of Mn‐based nanoplatforms, including immunotherapy alone, immunotherapy‐involved multimodal synergistic therapy, and imaging‐guided immunotherapy are discussed in detail. Finally, the challenges and future developments of Mn‐based tumor immunotherapy are highlighted.

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Recent Advances of Manganese-Based Hybrid Nanomaterials for Cancer Precision Medicine

Cited by 7 publications

References 89 publications

Review on Medical Applications of Manganese Oxide (Mn2+, Mn3+, and Mn4+) Magnetic Nanoparticles

Review on Medical Applications of Manganese Oxide (Mn2+, Mn3+, and Mn4+) Magnetic Nanoparticles

Tumor targeted nanohybrid for dual stimuli responsive and NIR amplified photothermal/photo-induced thermodynamic/chemodynamic combination therapy

Manganese‐Based Tumor Immunotherapy

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