Recent advances of injectable hydrogels for drug delivery and tissue engineering applications

Sun, Yining; Nan, Ding; Jin, Haiqiang; Qu, Xiaozhong

doi:10.1016/j.polymertesting.2019.106283

Cited by 158 publications

(113 citation statements)

References 167 publications

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“…Thus, compared to ordinary hydrogels, injectable hydrogels have recently drawn significant attention as drug delivery system (Figure 1). [11][12][13][14][15][16][17][18][19] Injectable hydrogels can be implanted through a minimally invasive procedure that can significantly reduce patients' discomfort and pain while decreasing healing time, be achieved at low cost, and be applied into hard-to-reach tissue sites. Thus, their clinical application is widespread.…”

Section: Injectable Hydrogelsmentioning

confidence: 99%

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Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Rizzo

Kehr

2020

Adv Healthcare Materials

183

152

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Injectable hydrogels have received considerable interest in the biomedical field due to their potential applications in minimally invasive local drug delivery, more precise implantation, and site‐specific drug delivery into poorly reachable tissue sites and into interface tissues, where wound healing takes a long time. Injectable hydrogels, such as in situ forming and/or shear‐thinning hydrogels, can be generated using chemically and/or physically crosslinked hydrogels. Yet, for controlled and local drug delivery applications, the ideal injectable hydrogel should be able to provide controlled and sustained release of drug molecules to the target site when needed and should limit nonspecific drug molecule distribution in healthy tissues. Thus, such hydrogels should sense the environmental changes that arise in disease states and be able to release the optimal amount of drug over the necessary time period to the target region. To address this, researchers have designed stimuli‐responsive injectable hydrogels. Stimuli‐responsive hydrogels change their shape or volume when they sense environmental stimuli, e.g., pH, temperature, light, electrical signals, or enzymatic changes, and deliver an optimal concentration of drugs to the target site without affecting healthy tissues.

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Section: Injectable Hydrogelsmentioning

confidence: 99%

“…For additional details on the synthesis and gelation mechanisms of injectable hydrogels, we suggest several recent review articles. [13,14,17,24,25]…”

Section: Injectable Hydrogelsmentioning

confidence: 99%

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Rizzo

Kehr

2020

Adv Healthcare Materials

183

152

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“…Regarding the thermo-responsive polymers, these have been thoroughly studied and exhibit a volume phase transition at a critical solution temperature (i.e., the temperature where exists a balance in the competition established by hydrophilic and hydrophobic chains), usually referred to as cloud point (Tcp), which is responsible for the changes in the solvation-state [37][38][39]. Usually, topical applications and injectable biodegradable scaffolds made of this type of polymers make use of body temperature to cause a change in the physical properties of the system [40].…”

Section: Thermo-responsive Smart Polymersmentioning

confidence: 99%

Bioengineered Scaffolds for Thermo-responsive Drug Delivery in Wound Healing

Henríquez¹,

Castro-Alpízar²,

Lopretti-Correa³

et al. 2020

Preprint

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innate and adaptive immune responses lead to wound healing by regulating a complex series of events promoting cellular cross-talk. An inflammatory response is presented with its characteristic clinical symptoms: heat, pain, redness, and swelling. Some smart thermo-responsive polymers like chitosan can be used to create biocompatible and biodegradable scaffolds with 3D architectures similar to human structures, allowing their efficient and safe use as tissue engineering and drug delivery systems in chronic wounds. Locally heated tumors above polymer lower critical solution temperature can induce its conversion into a hydrophobic form, enhancing drug release until the thermal stimulus is gone, where a lower release is due to the swelling of the material. This paper integrates the relevant reported contributions of bioengineered scaffolds for thermo-responsive drug delivery in wound healing. Therefore, we present a comprehensive review that aims to demonstrate the capacity of these systems to provide spatially and temporally controlled release strategies for one or more drugs used in wound healing. In this sense, the novel manufacturing techniques of 3D-printing and electrospinning are explored for the tuning of their physicochemical properties to adjust therapies according to the patient’s convenience, as well as reduce drug toxicity and side effects.

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“…In recent years, due to the growing number of traffic accidents and surgical interventions, innovative methods of treatment and regeneration of damaged tissues are sought. An interesting solution seems to be injectable hydrogels [ 1 , 2 , 3 ] that are obtained from synthetic and natural polymers. These materials, characterized by the three-dimensional architecture, have the ability to mimic the extracellular matrix [ 4 , 5 , 6 ], and thus support cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

Injectability of Thermosensitive, Low-Concentrated Chitosan Colloids as Flow Phenomenon through the Capillary under High Shear Rate Conditions

Rył¹,

Owczarz²

2020

Polymers

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Low-concentrated colloidal chitosan systems undergoing a thermally induced sol–gel phase transition are willingly studied due to their potential use as minimally invasive injectable scaffolds. Nevertheless, instrumental injectability tests to determine their clinical utility are rarely performed. The aim of this work was to analyze the flow phenomenon of thermosensitive chitosan systems with the addition of disodium β-glycerophosphate through hypodermic needles. Injectability tests were performed using a texture analyzer and hypodermic needles in the sizes 14G–25G. The rheological properties were determined by the flow curve, three-interval thixotropy test (3ITT), and Cox–Merz rule. It was found that reducing the needle diameter and increasing its length and the crosshead speed increased the injection forces. It was claimed that under the considered flow conditions, there was no need to take into account the viscoelastic properties of the medium, and the model used to predict the injection force, based solely on the shear-thinning nature of the experimental material, showed very good agreement with the experimental data in the shear rate range of 200–55,000 s−1. It was observed that the increase in the shear rate value led to macroscopic structural changes of the chitosan sol caused by the disentangling and ordering of the polysaccharide chains along the shear field.

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Recent advances of injectable hydrogels for drug delivery and tissue engineering applications

Cited by 158 publications

References 167 publications

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Bioengineered Scaffolds for Thermo-responsive Drug Delivery in Wound Healing

Injectability of Thermosensitive, Low-Concentrated Chitosan Colloids as Flow Phenomenon through the Capillary under High Shear Rate Conditions

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