Recent Advances of Gold Nanoparticles in Biomedical Applications: State of the Art

Aminabad, Negar Sedghi; Farshbaf, Masoud; Akbarzadeh, Abolfazl

doi:10.1007/s12013-018-0863-4

Cited by 102 publications

(57 citation statements)

References 66 publications

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“…Up to the present time, there are no Gd 3+ -bearing AuNPs that have been evaluated in clinical trials for MRI, and PET/MRI bimodal imaging studies are in general scarce [36][37][38][39]. While some studies have been done regarding the application of AuNPs for theranostics, their therapeutic function is mostly based on the photothermal properties of the AuNPs themselves or on the delivery of a payload acting as a cytotoxic drug [40][41][42][43][44][45][46]. There are some examples of AuNPs that have been evaluated in the delivery of medically relevant radionuclides, aiming to obtain "radiotheranostic" agents suitable to provide clear and sensitive tumor detection and selective therapeutic effects [47,48].…”

Section: Introductionmentioning

confidence: 99%

Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics

et al. 2020

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Gold nanoparticles (AuNPs) are interesting for the design of new cancer theranostic tools, mainly due to their biocompatibility, easy molecular vectorization, and good biological half-life. Herein, we report a gold nanoparticle platform as a bimodal imaging probe, capable of coordinating Gd3+ for Magnetic Resonance Imaging (MRI) and 67Ga3+ for Single Photon Emission Computed Tomography (SPECT) imaging. Our AuNPs carry a bombesin analogue with affinity towards the gastrin releasing peptide receptor (GRPr), overexpressed in a variety of human cancer cells, namely PC3 prostate cancer cells. The potential of these multimodal imaging nanoconstructs was thoroughly investigated by the assessment of their magnetic properties, in vitro cellular uptake, biodistribution, and radiosensitisation assays. The relaxometric properties predict a potential T1- and T2- MRI application. The promising in vitro cellular uptake of 67Ga/Gd-based bombesin containing particles was confirmed through biodistribution studies in tumor bearing mice, indicating their integrity and ability to target the GRPr. Radiosensitization studies revealed the therapeutic potential of the nanoparticles. Moreover, the DOTA chelating unit moiety versatility gives a high theranostic potential through the coordination of other therapeutically interesting radiometals. Altogether, our nanoparticles are interesting nanomaterial for theranostic application and as bimodal T1- and T2- MRI / SPECT imaging probes.

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Section: Introductionmentioning

confidence: 99%

Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics

et al. 2020

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“…AuNPs have unique chemical, optical, and electromagnetic properties, and their surface are highly compatible with the modification of a variety of drugs, antibodies, peptides, DNA, RNA, and multifunctional polymers. They have been widely explored for the delivery of antitumor agents (Aminabad et al, ; Sasidharan & Monteiro‐Riviere, ). Due to the challenges come with the conventional AuNPs, such as stealth from the endothelial reticular system (RES) and immune system, stimuli‐responsive AuNPs have been developed for enhanced the tumor penetration and accumulation (Grzelczak, Liz‐Marzan, & Klajn, ; L. Tian et al, ).…”

Section: Drug Delivery By Acid‐responsive Aunpsmentioning

confidence: 99%

Recent advances of smart acid‐responsive gold nanoparticles in tumor therapy

Yang

Liu

2020

WIREs Nanomed Nanobiotechnol

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Due to the remarkable properties of gold nanoparticles (AuNPs), they have been extensively employed as a potential tool for the diagnosis and treatment of cancers. While the conventional drug delivery system fails to efficiently deliver the chemotherapeutics due to the complexity of tumor microenvironment, people have been seeking alternative nanoparticulate strategy to improve the tumor specificity, the therapeutic index as wells as the pharmacokinetic profile. The nontoxic and nonimmunogenic nature, the high permeability, and superior retention effect of AuNPs provide additional benefits by enabling easy penetration and accumulation of drugs at the tumor sites. Here in this review, we focused on discussing the recent advances regarding the design of acid‐responsive AuNPs as well as their applications in drug/gene delivery and imaging in cancer diagnosis and therapy. Particularly, we highlighted the size switch strategies used in the development of acid‐responsive AuNPs. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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“…A thermocouple was used for the measurement of photothermal temperature based on previous reports [23][24][25][29][30][31]. The thermocouple measurement used Delta OHM HD2128.2 T-type.…”

Section: Photothermal Measurementsmentioning

confidence: 99%

“…Recent advances in the multi-functional design of GNPs allow for the generation of localized heat in the proximity of cancer tissues and additionally allow the delivery of multiple desired drugs in a controlled and targeted manner. GNPs have many benefits that make them suitable for the photothermal treatment of tumor or cancer, because they can be delivered into the local tumor area while minimizing nonspecific distribution, activated via near-infrared (NIR) laser light, creating the ability to penetrate deep into biological tissues, and modulated to create multifaceted cancer photothermal therapy [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

“…The microstructure of the as-prepared nanocomposites will be characterized, and the possible formation mechanisms will be understood. The photothermal property of Au@C nanostructures, as a case study, will be examined, by referring to recent studies [23][24][25]. This study may offer a facile but effective strategy to prepare carbonaceous metal nanocomposites with potential applications in material science, catalysis, and biochemistry.…”

Section: Introductionmentioning

confidence: 99%

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Development of a General Fabrication Strategy for Carbonaceous Noble Metal Nanocomposites with Photothermal Property

Zhu

Jiang

2020

Nanoscale Res Lett

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This study demonstrates a simple hydrothermal method while can be generalized for controllable synthesis of noble metallic carbonaceous nanostructures (e.g., Au@C, Ag@C) under mild conditions (180-200°C), which also provides a unique approach for fabricating hollow carbonaceous structures by removal of cores (e.g., silver) via a redox etching process. The microstructure and composition of the as-achieved nanoparticles have been characterized using various microscopic and spectroscopic techniques. Cetyltrimethylammonium bromide (CTAB), serving as a surfactant in the reaction system, plays a key role in the formation of Ag@C, Au@C nanocables, and their corresponding hollow carbonaceous nanotubes in this work. The dynamic growth and formation mechanism of carbonaceous nanostructures was discussed in detail. And finally, laser-induced photothermal property of Au@C nanocomposites was examined. The results may be useful for designing and constructing carbonaceous metal(s) or metal oxide(s) nanostructures with potential applications in the areas of electrochemical catalysis, energy storage, adsorbents, and biomedicine.

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Recent Advances of Gold Nanoparticles in Biomedical Applications: State of the Art

Cited by 102 publications

References 66 publications

Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics

Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics

Recent advances of smart acid‐responsive gold nanoparticles in tumor therapy

Development of a General Fabrication Strategy for Carbonaceous Noble Metal Nanocomposites with Photothermal Property

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