Analysis is carried out for a single span wavelength division multiplexing (WDM) transmission system with distributed Raman amplification to find the effect of amplifier induced crosstalk on the bit error rate (BER) with different system parameters. The results are evaluated in terms of crosstalk power induced in a WDM channel due to Raman amplification, optical signal to crosstalk ratio (OSCR) and BER at any distance for different pump power and number of WDM channels. The results show that the WDM system suffers power penalty due to crosstalk which is significant at higher pump power, higher channel separation and number of WDM channel. It is noticed that at a BER 10 −9 , the power penalty is 8.7 dB and 10.5 dB for the length of 180 km and number of WDM channel N = 32 and 64 respectively when the pump power is 20 mW and is higher at high pump power. Analytical results are validated by simulation.