Recent advances: Medical microbiology

Richardson, Harold; Smaill, Fiona

doi:10.1136/bmj.317.7165.1060

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…A centroid tracking algorithm was used to count the number of bacteria in each region, as shown in supplemental Figure S2(f). S. aureus bacterium has a maximum diameter of approximately 1 μm, 38 therefore two bacterial point spread functions were considered distinct only if separated by greater than 4 pixels (1.52 μm). Moreover, to prevent counting bacteria more than once, all cross-sectional profiles analyzed were separated by a minimum distance of 1.14 μm.…”

Section: Quantifying Bacteria At Different Sc Depthsmentioning

confidence: 99%

Lipid depletion enables permeation of Staphylococcus aureus bacteria through human stratum corneum

2020

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Atopic dermatitis (AD) is a chronic inflammatory disease that affects approximately 2-5% of adults worldwide. The pathogenesis of AD continues to be a well-debated point of conjecture, with numerous hypotheses having been proposed. AD conditions are associated with increased populations of Staphylococcus aureus and reduced skin lipids. In this study, we evaluate the ability of S. aureus to permeate across human stratum corneum (SC) exhibiting both normal and depleted lipid conditions consistent with AD. This permeation would enable bacteria to interact with underlying viable epidermal cells, which could serve as a trigger for inflammation and disease onset. Our results indicate that permeation of S. aureus through SC exhibiting normal lipid conditions is not statistically significant. However, bacteria can readily permeate through lipid depleted tissue over a 9-d period. These findings suggest that S. aureus may potentially act as the mechanistic cause, rather than merely the result of AD.

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Section: Quantifying Bacteria At Different Sc Depthsmentioning

confidence: 99%

Lipid depletion enables permeation of Staphylococcus aureus bacteria through human stratum corneum

2020

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“…Non-typhoidal salmonellosis is a worldwide disease of humans and animals. Animals are the main reservoir, and the disease is usually foodborne, although it can be spread from person to person [ 104 ]. Around the world, several outbreaks of food poisoning related to Salmonella are documented, e.g., an outbreak of infection with non-typhoidal Salmonella affecting 396 patients in the community was associated with frozen pies supplied for cooking by the consumer in a microwave oven [ 105 ].…”

Section: Antibacterial Potential Of Bioactive Compounds From Macromentioning

confidence: 99%

Antibacterial Use of Macroalgae Compounds against Foodborne Pathogens

Silva

Lourenço-Lopes

et al. 2020

Antibiotics

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The search for food resources is a constant in human history. Nowadays, the search for natural and safe food supplies is of foremost importance. Accordingly, there is a renewed interest in eco-friendly and natural products for substitution of synthetic additives. In addition, microbial contamination of food products during their obtaining and distribution processes is still a sanitary issue, and an important target for the food industry is to avoid food contamination and its related foodborne illnesses. These diseases are fundamentally caused by certain microorganisms listed in this review and classified according to their Gram negative or positive character. Algae have proven to possess high nutritional value and a wide variety of biological properties due to their content in active compounds. Among these capabilities, macroalgae are recognized for having antimicrobial properties. Thus, the present paper revises the actual knowledge of microbial contaminants in the food industry and proposes antimicrobial algal compounds against those pathogenic bacteria responsible for food contamination as valuable molecules for its growth inhibition. The capacity of algae extracts to inhibit some major food pathogen growth was assessed. Moreover, the main applications of these compounds in the food industry were discussed while considering their favorable effects in terms of food safety and quality control.

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“…Sekitar 80% penyakit yang tertular melalui makanan disebabkan oleh bakteri pathogen [2]. Beberapa jenis bakteri yang sering menimbulkan penyakit antara lain: Staphylococcus aureus, Bacillus cereus, Clostridum perferingens, Escherichia coli, Vibrio cholera, Shigella sp, Salmonella sp, Clostridium difficile, Compylobacter jejuni, Yersinia entrolitica, Klebsiella pnemontae, dan Vibrio haemolyticus [3]. Salah satu akibat dari keracunan makanan yaitu diare.…”

Section: Pendahuluanunclassified

“…Salah satu akibat dari keracunan makanan yaitu diare. Diare merupakan suatu gejala klinis dari gangguan pencernaan (usus) yang ditandai dengan bertambahnya frekuensi defekasi lebih dari biasanya yang berulang-ulang yang disertai adanya perubahan bentuk dan konsistensi feses menjadi lembek atau cair [3].…”

Section: Pendahuluanunclassified

Potential of Antibacterial Compounds from Sweet Root Extract (Glycyrrhiza glabra L) on Bacillus cereus

2019

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The high number of poisoning food and diarrheal diseases caused by Bacillus cereus bacteria has been treated with chemical drugs and traditionally herbal plants. One of the commonly used herbal plants is sweet root (Glycyrrhiza glabra L.). This study aims to extract and fractionate sweet root plants, determine the antibacterial activity and identify the types of bioactive compounds as antibacterial compounds. The extraction process uses a maceration technique and fractionation using buthanol, ethyl acetate, and hexan solvents. Antibacterial activity was carry out by the diffusion method and identification of bioactive compounds by GCMS analysis. This study showed that greatest antibacterial activity was found in ethyl acetate fraction with a strong category and MIC value of 12,5%. This study for the first time also revealed that the types of bioactive compounds from sweet root plants (Glycyrrhiza glabra L.) as antibacterial compounds are n-Hexadecanoic as a fatty acid group and 4H-Pyran 4-one 2.3 dihydro-3, 5-dihydroxy-6 methyl from the flavonoid group.

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Recent advances: Medical microbiology

Cited by 7 publications

References 19 publications

Lipid depletion enables permeation of Staphylococcus aureus bacteria through human stratum corneum

Lipid depletion enables permeation of Staphylococcus aureus bacteria through human stratum corneum

Antibacterial Use of Macroalgae Compounds against Foodborne Pathogens

Potential of Antibacterial Compounds from Sweet Root Extract (Glycyrrhiza glabra L) on Bacillus cereus

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