Recent advances in understanding tight junctions

Furuse, Mikio; Takai, Yoshimi

doi:10.12703/r/10-18

Cited by 12 publications

(10 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tight junctions (also called occluding junctions or zonulae occludentes) are claudin-mediated intercellular attachment structures linked with actin cytoskeletons, characterized by the morphology of kissing points under the electron microscope [12][13][14][15].…”

Section: Types Of Epithelial Junctions and Their Tissue-specific Distributionmentioning

confidence: 99%

“…Tight junctions (also called occluding junctions or zonulae occludens) are claudin-mediated intercellular attachment structures linked with actin cytoskeletons, characterized by the morphology of kissing points under the electron microscope [12][13][14][15]. Adherens junctions (also known as zonula adherens or intermediate junctions) are cadherin/catenin-based complexes connecting the actin belt, usually localized between tight junctions and desmosomes [16].…”

Section: Types Of Epithelial Junctions and Their Tissue-specific Dist...mentioning

confidence: 99%

See 1 more Smart Citation

Junctional complexes in epithelial cells: sentinels for extracellular insults and intracellular homeostasis

Jiang

et al. 2021

The FEBS Journal

View full text Add to dashboard Cite

The cell-cell and cell-ECM junctions within the epithelial tissues are crucial anchoring structures that provide architectural stability, mechanical resistance and permeability control. Their indispensible role as signaling hubs orchestrating cell shape-related changes such as proliferation, differentiation, migration and apoptosis has also been well recognized. However, growing amount of evidence now suggests that the multitasking nature of epithelial junctions extends well beyond anchorage-dependent or cell shape change-related biological processes. In this review, we discuss the emerging roles of junctional complexes in regulating innate immune defense, stress resistance and intracellular proteostasis of the epithelial cells, with emphasis on the upstream regulation of epithelial junctions on various aspects of the epithelial barrier.

show abstract

Section: Types Of Epithelial Junctions and Their Tissue-specific Distributionmentioning

confidence: 99%

Section: Types Of Epithelial Junctions and Their Tissue-specific Dist...mentioning

confidence: 99%

Junctional complexes in epithelial cells: sentinels for extracellular insults and intracellular homeostasis

Jiang

et al. 2021

The FEBS Journal

View full text Add to dashboard Cite

show abstract

“…E‐Cadherin and nectin are major components of the AJs (Takai et al, 2008; Takeichi, 2014), whereas claudin, occludin, tricellulin, and junctional adhesion molecule (JAM) are major components of TJs (Tsukita et al, 2001; Otani & Furuse, 2020; Furuse & Takai, 2021). The AJs are extensively undercoated with filamentous actin (F‐actin) via a large number of F‐actin‐binding proteins (FABPs) (Maruthamuthu et al, 2010; Efimova & Svitkina, 2018; Steinbacher & Ebnet, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…The AJs are extensively undercoated with filamentous actin (F‐actin) via a large number of F‐actin‐binding proteins (FABPs) (Maruthamuthu et al, 2010; Efimova & Svitkina, 2018; Steinbacher & Ebnet, 2018). For example, αE‐catenin for E‐cadherin, afadin for nectin, and ZO‐1, ZO‐2, and ZO‐3 for claudin, occludin, tricellulin, and JAM are major FABPs at the AJs and the TJs (Takai et al, 2008; Takeichi, 2014; Furuse & Takai, 2021). These AJ and TJ components cooperatively organize the AJC: nectin first initiates cell adhesion and recruits E‐cadherin to the nectin‐mediated cell adhesion sites by the binding of afadin to αΕ‐catenin, enhancing the trans ‐interaction of E‐cadherin to form the AJs during and/or after the formation of the AJs, and trans ‐interacting nectin enhances the recruitment of first JAM and then claudin and occludin to the apical side of the AJs by the binding of afadin to ZO‐1 to form the TJs, eventually establishing the AJC (Takai et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Stimulatory role of nectin‐4 and p95‐ErbB2 in multilayered T47D cell proliferation

et al. 2022

Self Cite

View full text Add to dashboard Cite

Multilayered proliferation in an adherent culture as well as proliferation in a suspension culture is a characteristic feature of cancer cells. We previously showed using T47D human mammary cancer cells that nectin-4, upregulated in many cancer cells, cis-interacts with ErbB2 and its trastuzumab-resistant splice variants, p95-ErbB2 and ErbB2ΔEx16, and enhances DNA synthesis mainly through the PI3K-AKT pathway in an adherent culture. We showed here that only the combination of nectin-4 and p95-ErbB2, but not that of nectin-4 and ErbB2 or that of nectin-4 and ErbB2ΔEx16, cooperatively enhanced multilayered T47D cell proliferation through the Hippo pathwaymediated SOX2 gene expression in an adherent culture. T47D cells expressed the components of the apical junctional complex (AJC) consisting of adherens junctions (AJs) and tight junctions and cell polarity molecules, but not the AJ component afadin. The AJC and apicobasal polarity were disorganized in T47D cells in a monolayer and T47D cells stably expressing both nectin-4 and p95-ErbB2 in multilayers. These results indicate that nectin-4 and p95-ErbB2 play a stimulatory role in multilayered proliferation in an adherent culture.

show abstract

“…Major epithelial AJ cell adhesion molecules (CAMs) are cadherin, especially E-cadherin, and nectin ( 8 , 9 ), whereas major epithelial TJ CAMs are claudin and junctional adhesion molecule (JAM) ( 2 , 6 , 10 ). Occludin and tricellulin are also the components of TJs, although they are not typical CAMs ( 11 , 12 ).…”

mentioning

confidence: 99%

Identification of lysophosphatidic acid in serum as a factor that promotes epithelial apical junctional complex organization

Sakakibara¹,

Sakane²,

Sasaki³

et al. 2022

Journal of Biological Chemistry

Self Cite

View full text Add to dashboard Cite

Recent advances in understanding tight junctions

Cited by 12 publications

References 24 publications

Junctional complexes in epithelial cells: sentinels for extracellular insults and intracellular homeostasis

Junctional complexes in epithelial cells: sentinels for extracellular insults and intracellular homeostasis

Stimulatory role of nectin‐4 and p95‐ErbB2 in multilayered T47D cell proliferation

Identification of lysophosphatidic acid in serum as a factor that promotes epithelial apical junctional complex organization

Contact Info

Product

Resources

About