Recent Advances in Understanding the Human Fungal Pathogen Hypoxia Response in Disease Progression

Puerner, Charles; Vellanki, Sandeep; Strauch, Julianne L.; Cramer, Robert A.

doi:10.1146/annurev-micro-032521-021745

Cited by 5 publications

(1 citation statement)

References 130 publications

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“…This local hypoxia is exacerbated by structural damage to the vascular system, resulting in reduced oxygen delivery. The restricted availability of oxygen induces a hypoxic response in the fungi, ultimately contributing to increased levels of HIF-1α [ 68 ]. HIF-1α plays a protective role in fungal infections by effectively reducing Candida albicans colonization in the gastrointestinal tract, as demonstrated in research [ 69 ].…”

Section: Infection-induced Modulation Of Hif-1α In Sepsismentioning

confidence: 99%

Unraveling the role of HIF-1α in sepsis: from pathophysiology to potential therapeutics—a narrative review

Ruan,

Zhang,

Zhang

et al. 2024

Crit Care

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Sepsis is characterized by organ dysfunction resulting from a dysregulated inflammatory response triggered by infection, involving multifactorial and intricate molecular mechanisms. Hypoxia-inducible factor-1α (HIF-1α), a notable transcription factor, assumes a pivotal role in the onset and progression of sepsis. This review aims to furnish a comprehensive overview of HIF-1α's mechanism of action in sepsis, scrutinizing its involvement in inflammatory regulation, hypoxia adaptation, immune response, and organ dysfunction. The review encompasses an analysis of the structural features, regulatory activation, and downstream signaling pathways of HIF-1α, alongside its mechanism of action in the pathophysiological processes of sepsis. Furthermore, it will delve into the roles of HIF-1α in modulating the inflammatory response, including its association with inflammatory mediators, immune cell activation, and vasodilation. Additionally, attention will be directed toward the regulatory function of HIF-1α in hypoxic environments and its linkage with intracellular signaling, oxidative stress, and mitochondrial damage. Finally, the potential therapeutic value of HIF-1α as a targeted therapy and its significance in the clinical management of sepsis will be discussed, aiming to serve as a significant reference for an in-depth understanding of sepsis pathogenesis and potential therapeutic targets, as well as to establish a theoretical foundation for clinical applications. Graphical Abstract

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Section: Infection-induced Modulation Of Hif-1α In Sepsismentioning

confidence: 99%