Recent advances in understanding the role of high fat diets and their components on hematopoiesis and the hematopoietic stem cell niche

Thermal adaptation and fatty acid profiles of bone marrow and muscles in mammals: Implications of a study of caribou (Rangifer tarandus caribou)

“…In the caribou females that we sampled, both scored as prime adults, the epiphyseal regions of the long bones were apparently actively involved in hematopoiesis, as suggested by the greater concentrations of total n-6 and n-3 PUFA observed in the extremities of long bones. Vanhie et al [ 45 ] reported that PUFA of the n-6 and n-3 families may have distinct effects on hematopoiesis in studies conducted in vitro. Moreover, n-3 PUFA appear to decrease inflammation and provide substrates for β-oxidation, which is known to play an important role in hematopoiesis regulation [ 45 ].…”

“…Vanhie et al [ 45 ] reported that PUFA of the n-6 and n-3 families may have distinct effects on hematopoiesis in studies conducted in vitro. Moreover, n-3 PUFA appear to decrease inflammation and provide substrates for β-oxidation, which is known to play an important role in hematopoiesis regulation [ 45 ]. If confirmed under more controlled experimental conditions, this finding would be consistent with observations made in humans and many other mammals [ 15 ].…”