Recent Advances in Understanding the Mechanistic Role of Transient Receptor Potential Ion Channels in Patients With Hypertension

Rios, Francisco J.; Sarafian, Raquel D.; Camargo, Livia L.; Montezano, Augusto C.; Touyz, Rhian M.

doi:10.1016/j.cjca.2023.10.009

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Trp Channels1

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2024

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“…87 Changes in several TRP channels have been implicated in amplified vascular reactivity in hypertension. 88 Here, we will only summarize some milestone papers on the potential contribution of VSMC TRPC3 and TRPV4 channels to hypertension.…”

Section: Trp Channelsmentioning

confidence: 99%

Milestone Papers on Signal Transduction Mechanisms of Hypertension and Its Complications

Eguchi,

Torimoto,

Adebiyi

et al. 2024

Hypertension

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To celebrate 100 years of AHA-supported cardiovascular disease research, this review article highlights milestone papers that have significantly contributed to the current understanding of the signaling mechanisms driving hypertension and associated cardiovascular disorders. This article also includes a few of the future research directions arising from these critical findings. To accomplish this important mission, 4 principal investigators gathered their efforts to cover distinct yet intricately related areas of signaling mechanisms pertaining to the pathogenesis of hypertension. The renin-angiotensin system, canonical and novel contractile and vasodilatory pathways in the resistance vasculature, vascular smooth muscle regulation by membrane channels, and noncanonical regulation of blood pressure and vascular function will be described and discussed as major subjects.

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Section: Trp Channelsmentioning

confidence: 99%