Recent advances in understanding bile duct remodeling and fibrosis

Scrushy, Marinda; O’Brien, April; Glaser, Shannon

doi:10.12688/f1000research.14578.1

Cited by 3 publications

(3 citation statements)

References 32 publications

(55 reference statements)

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“…The origin of the DR in liver pathology and the determinant factor that initiates the regenerative process remain unclear 15,16 . Recent findings have shown that progenitor stem‐like cells play a crucial role in biliary epithelium restoration and hepatocyte regeneration 40,41 . As progenitor cells express unique regenerative qualities and seem to be associated with liver tissue fibrosis, they have become an interesting target for the development of novel therapeutic options to tackle biliary injury 42,43 .…”

Section: Discussionmentioning

confidence: 99%

“…15,16 Recent findings have shown that progenitor stem-like cells play a crucial role in biliary epithelium restoration and hepatocyte regeneration. 40,41 As progenitor cells express unique regenerative qualities and seem to be associated with liver tissue fibrosis, they have become an interesting target for the development of novel therapeutic options to tackle biliary injury. 42,43 With K7-AI model 2.0, DR can be quantified precisely and reproducibly.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Automated image analysis of keratin 7 staining can predict disease outcome in primary sclerosing cholangitis

Sjöblom

Boyd

Manninen

et al. 2022

Hepatology Research

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Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that can lead to liver cirrhosis or cholangiocarcinoma. Here, we developed a K7-AI model 2.0 to analyze K7-stained liver specimens of patients with PSC. We found that the K7-AI model 2.0 can serve as a prognostic tool for clinical endpoints, since it was able to provide significant information on disease outcomes based on different histological features.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Automated image analysis of keratin 7 staining can predict disease outcome in primary sclerosing cholangitis

Sjöblom

Boyd

Manninen

et al. 2022

Hepatology Research

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“…Intra-operative sonography can provide precise information on duct size and peripheral dilatation as early as 4 h after biliary obstruction, while intra-hepatic bile duct dilatation after five days. 20,[22][23][24][25] This was carried out in the current study with pigs prior to and following graft implant surgery which the transducer being placed directly on the hepatic surface. 26,27 The graft did not change the diameter of the CBD an average of 2.9 mm considered a normal size and AP on average of 96.8 mm.…”

Section: Discussionmentioning

confidence: 99%

Use of bacterial cellulose film for repair of bile duct injury in pigs

et al. 2020

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Background/objective The aim was to evaluate the use of bacterial cellulose film and bile duct autograft in repairing critical common bile duct injury in pigs. Methods A prospective experimental analytical study was carried out on 20 Sus Domesticus, Piau suidae swine, divided into a control group ( n = 10) and an experimental group ( n = 10) divided into two subgroups: bacterial cellulose film E1 and bacterial cellulose film E2 to which bacterial cellulose film was randomly allocated. The control group underwent two complete critical common bile duct sections 10 mm apart, while the experimental group with a single critical common bile duct defect underwent a 10 mm section of the longitudinal shaft with edge resection. The defects in the control group were treated with end-to-end conventional anastomosis using polyglycolic 6–0 surgical thread and the experimental group with bacterial cellulose film by continuous suture using the same material. The animals were clinically evaluated throughout the experiment on days D150 (bacterial cellulose film E1), D225 (control group), and D330 (bacterial cellulose film E2) and by intraoperative ultrasound examination related to histopathological and biochemical findings. Results The intraoperative ultrasonography detected the changes resulting from the common bile duct anastomosis in the control group that produced a considerable incidence of ductal narrowing and obstruction to the biliary flow. In the bacterial cellulose film E2 group, there was an increase in inflammation intensity, granulomatous reaction, fibrosis, and vessels density, without producing bile duct dilation in the ultrasonography assessment. Biochemical analysis of liver enzymes yielded results in the normal range confirming preservation of liver function at the different post-surgery time points. Conclusion Bacterial cellulose film, when used as a graft for bile duct repair, proved to be a biocompatible material that produced a complete healing process and biliary flow continuity.

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Diagnostic dilemma in a patient with history of medullary thyroid carcinoma and abnormal serum liver enzymes; a case report with six years follow up

Rahmani,

Tohidi,

Azmoudeh-Ardalan

et al. 2023

BMC Endocr Disord

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Background Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor that originates from parafollicular C-cells. Calcitonin (Ctn) and carcinoembryonic antigen (CEA) are useful biomarkers for monitoring MTC cases. Case presentation Here, we describe a 48-year-old woman, who presented in 2014 with bilateral thyroid nodules. Report of fine needle aspiration was suspicious for MTC; initial laboratory evaluation showed serum Ctn level of 1567 pg/mL. After excluding type 2 multiple endocrine neoplasia syndrome clinically, total thyroidectomy and neck lymph node dissection were performed. The final histopathological diagnosis was right lobe MTC with neither vascular invasion nor lymph node involvement. On regular follow-up visits, Ctn and CEA levels have been undetectable, and repeated cervical ultrasonographic exams were unremarkable from 2014 to 2021. As liver enzymes became elevated in 2016, the patient was further evaluated by a gastroenterologist. Abdominopelvic ultrasonography revealed a coarse echo pattern of the liver parenchyma with normal bile ducts. A liver fibroscan showed a low fibrosis score (7kPa). The patient was recommended to use ursodeoxycholic acid. According to the progressive rise of liver enzymes with a cholestatic pattern in October 2020, a liver biopsy was performed that showed tiny nests of neuroendocrine-like cells with a background of primary biliary cholangitis (PBC). Immunohistochemical stainings were positive for chromogranin A (CgA), and synaptophysin and negative for Ctn, CEA, and thyroglobulin. Further imaging investigations did not reveal any site of a neuroendocrine tumor in the body. Considering normal physical exam, imaging findings, as well as normal serum levels of Ctn, CEA, CgA, and procalcitonin, the patient was managed as a PBC. Conclusion In follow-up of a patient with MTC, we reported progressively increased liver enzymes with a cholestatic pattern. Liver biopsy revealed nests of neuroendocrine-like cells with a background of PBC, the findings that might suggest acquiring neuroendocrine phenotype by proliferating cholangiocytes.

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Recent advances in understanding bile duct remodeling and fibrosis

Cited by 3 publications

References 32 publications

Automated image analysis of keratin 7 staining can predict disease outcome in primary sclerosing cholangitis

Automated image analysis of keratin 7 staining can predict disease outcome in primary sclerosing cholangitis

Use of bacterial cellulose film for repair of bile duct injury in pigs

Diagnostic dilemma in a patient with history of medullary thyroid carcinoma and abnormal serum liver enzymes; a case report with six years follow up

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