Recent advances in ultrasound-based diagnosis and therapy with micro- and nanometer-sized formulations

Güvener, Nihan; Appold, Lia; Lorenzi, Federica; Golombek, Susanne K.; Rizzo, Larissa Yokota; Lammers, Twan; Kießling, Fabian

doi:10.1016/j.ymeth.2017.05.018

Cited by 84 publications

(71 citation statements)

References 128 publications

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“…The ability of US to induce cell toxicity was largely demonstrated in the literature and US-based therapeutic applications are currently used in the clinical setting [146][147][148][149], as further detailed in the chapter 7 of this review.…”

Section: Us-related Toxicitymentioning

confidence: 99%

“…Recently, nanoscale UCAs like nanobubbles, echogenic liposomes, micelles and nanodroplets were proposed to overcome the size limit of the MBs [146]. Indeed, in contrast to MBs, the above-mentioned nanostructures are able to extravasate from the blood vessels to the tissues and transport the drugs deeper into the malignant cells, enabling new theranostic capabilities.…”

Section: Clinical Applications Of Nps Assisted Ultrasound In Cancer Tmentioning

confidence: 99%

“…Although a lot of refinements concerning nanoscale UCAs are currently ongoing and it is expectable a substantial impact on future drug delivery field, their clinical translation has not been initiated so far [177]. Doxorubicin-containing liposomes were widely used in ultrasound-based drug delivery studies [146]. The reason for their popularity in the research studies resides in fact that several forms, known as Doxil, Caelyx, DaunoXome and Myocet, are already clinically approved by FDA [180].…”

Section: Clinical Applications Of Nps Assisted Ultrasound In Cancer Tmentioning

confidence: 99%

See 2 more Smart Citations

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

328

247

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• Ultrasound-based therapies are opening new horizons in the oncological field.• Innovative and promising solutions derive from different nanoparticles-assisted ultrasound treatments.• Sonodynamic therapy (SDT) emerged recently as a novel approach for cancer treatment.• Different and complex cell death mechanisms are involved in nanoparticles-assisted SDT.• Nanoparticles-assisted ultrasound is still at its infancy in clinics. A R T I C L E I N F O Keywords:Inertial cavitation Reactive oxygen species Sonoluminescence Sonodynamic Tumor Therapy Cytotoxicity A B S T R A C TAt present, ultrasound radiation is broadly employed in medicine for both diagnostic and therapeutic purposes at various frequencies and intensities. In this review article, we focus on therapeutically-active nanoparticles (NPs) when stimulated by ultrasound. We first introduce the different ultrasound-based therapies with special attention to the techniques involved in the oncological field, then we summarize the different NPs used, ranging from soft materials, like liposomes or micro/nano-bubbles, to metal and metal oxide NPs. We therefore focus on the sonodynamic therapy and on the possible working mechanisms under debate of NPs-assisted sonodynamic treatments. We support the idea that various, complex and synergistics physical-chemical processes take place during acoustic cavitation and NP activation. Different mechanisms are therefore responsible for the final cancer cell death and strongly depends not only on the type and structure of NPs or nanocarriers, but also on the way they interact with the ultrasonic pressure waves. We conclude with a brief overview of the clinical applications of the various ultrasound therapies and the related use of NPs-assisted ultrasound in clinics, showing that this very innovative and promising approach is however still at its infancy in the clinical cancer treatment.

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Section: Us-related Toxicitymentioning

confidence: 99%

Section: Clinical Applications Of Nps Assisted Ultrasound In Cancer Tmentioning

confidence: 99%

Section: Clinical Applications Of Nps Assisted Ultrasound In Cancer Tmentioning

confidence: 99%

See 1 more Smart Citation

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

328

247

View full text Add to dashboard Cite

show abstract

“…Limitations of the first generation of MBs were addressed either by incorporating the echogenic reflective air component into less permeable coatings, such as organic polymers and cross-linked proteins, or by employing less soluble gaseous compounds [43]. Since the first PBCA MBs developed by Harris et al, several antibodies and peptides were employed to produce targeted PBCA MBs with a multi-step synthesis for molecular ultrasound imaging [44].…”

Section: Preparation and Characterization Of Microbubblesmentioning

confidence: 99%

Functionalized polymer microbubbles as new molecular ultrasound contrast agent to target P-selectin in thrombus

Aid‐Launais

Labour

et al. 2019

Biomaterials

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Thrombotic diseases rarely cause symptoms until advanced stage and sudden death. Thus, early detection of thrombus by a widely spread imaging modality can improve the prognosis and reduce mortality. Here, polymer microbubbles (MBs) made of degradable poly(IsoButylCyanoAcrylate) and functionalized with fucoidan (Fucoidan-MBs) were designed as a new targeted ultrasound contrast agent to image venous thrombus. The physicochemical characterizations demonstrate that the MBs with fucoidan surface exhibit a size of 2-6 μm and stability in suspension at 4°C up to 2 months. MBs exhibit high echogenicity and could be completely burst under high destructive pulse. Flow chamber experiments on activated human platelets show a higher affinity of Fucoidan-MBs than control anionic MBs (CM-Dextran-MBs) under shear stress conditions. In vivo analysis by ultrasound and histological results demonstrate that Fucoidan-MBs are localized in rat venous thrombotic wall, whereas few CM-Dextran-MBs are present. In addition, the binding of Fucoidan-MBs in healthy vein is not observed. Collectively, Fucoidan-MBs appear as a promising functionalized carrier for ultrasound molecular imaging in thrombotic diseases.

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“…[84] As mechanical wave, ultrasounds can also attain spatiotemporal control over the drug release among the target sites. [84] As mechanical wave, ultrasounds can also attain spatiotemporal control over the drug release among the target sites.…”

Section: Ultrasound-triggered Deliverymentioning

confidence: 99%

The Horizon of the Emulsion Particulate Strategy: Engineering Hollow Particles for Biomedical Applications

Xia

et al. 2018

Advanced Materials

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With their hierarchical structures and the substantial surface areas, hollow particles have gained immense research interest in biomedical applications. For scalable fabrications, emulsion-based approaches have emerged as facile and versatile strategies. Here, the recent achievements in this field are unfolded via an "emulsion particulate strategy," which addresses the inherent relationship between the process control and the bioactive structures. As such, the interior architectures are manipulated by harnessing the intermediate state during the emulsion revolution (intrinsic strategy), whereas the external structures are dictated by tailoring the building blocks and solidification procedures of the Pickering emulsion (extrinsic strategy). Through integration of the intrinsic and extrinsic emulsion particulate strategy, multifunctional hollow particles demonstrate marked momentum for label-free multiplex detections, stimuli-responsive therapies, and stem cell therapies.

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Recent advances in ultrasound-based diagnosis and therapy with micro- and nanometer-sized formulations

Cited by 84 publications

References 128 publications

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Functionalized polymer microbubbles as new molecular ultrasound contrast agent to target P-selectin in thrombus

The Horizon of the Emulsion Particulate Strategy: Engineering Hollow Particles for Biomedical Applications

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