Recent Advances in Transition-Metal-Catalyzed Enantioselective Syntheses of Planar Chiral Ferrocenes

Abstract

Planar chiral ferrocene derivatives have been proved to be effective ligands and catalysts in asymmetric catalysis. The study toward enantioselective synthesis of planar chiral ferrocenes became one of the high hot spots. In this paper, the recent advance in transition-metal-catalyzed menthods for the syntheses of planar chiral ferrocenes is reviewed.

Asymmetric C–H Bond Functionalization of Ferrocenes: New Opportunities and Challenges

“…Surprisingly, this field has been stagnant for a long time since this work. Recently, accompanied by transition-metal-catalyzed enantioselective C-H activation reactions, significant progress has also been made in the synthesis of planar chiral ferrocenes (Figure 1F) [41][42][43][44][45][46]. In The development of appropriate catalytic systems allows enantioselective C-C bond formation starting from readily available ferrocenes.…”

Catalytic asymmetric synthesis of planar-chiral dianthranilides via (Dynamic) kinetic resolution

“…In sharp contrast, planar chirality arising from the destruction of symmetry on a single planar ring has received less attention 7 . Metallocenes [8][9][10][11][12][13] , cyclophanes [14][15][16][17][18][19][20][21] , and some rigid cycloalkenes [22][23][24][25][26][27][28] are typical planar-chiral structures. With recognition of the importance of planar chirality, particularly in chiral ligand/catalyst discovery [29][30][31][32][33] , several catalytic enantioselective synthesis methods have been developed [34][35][36][37][38][39] .…”

Structures and Synthetic Strategies of Chiral Oxazolinyl Ferrocene Derivatives

“…利用邻位锂化引入平面手性的过程有其优点, 但所 需高活性试剂(丁基锂)、反应助剂及低温反应条件等不 利因素, 促使研究者寻找更高效的合成方法. 以过渡金 属催化的方式, 同样利用手性噁唑啉为导向基团, 通过 碳-氢活化的方式, 可直接获得高立体选择性的平面手 性二茂铁化合物 [5,[78][79][80] . 这种方法进一步扩展了平面手 性基团种类, 有助于进一步突破现有平面手性噁唑啉二 茂铁化合物结构和应用范围.…”