Recent advances in transition metal-catalyzed heteroannulative difunctionalization of alkenes via C–H activation for the synthesis of heterocycles

Abstract

Heterocyclic compounds are the fundamental structural motifs distributed in natural products, pharmaceuticals and biologically active compounds. Thus, there is increasing interest in the development of novel synthetic strategies for the...

Rh-Catalyzed Cascade C-H Activation/Annulation of N-Hydroxybenzamides and Propargylic Acetates for Modular Access to Isoquinolones

“…In the last few decades, transition-metal-catalyzed C-H activation/annulations have been recognized as a powerful and straightforward approach for the synthesis of N -heterocycles and, therefore, have attracted increasing attention [ 17 , 18 , 19 , 20 ]. Recently, the transition-metal-catalyzed oxidative cyclization of N -substituted benzamides with symmetrical alkynes or diazos via C-H bond activation has been an efficient method for constructing N -protected isoquinolone derivatives [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ].…”

Intermolecular Redox-Neutral Carboamination of C–C Multiple Bonds Initiated by Transition-Metal-Catalyzed C–H Activation

“…These reactions involve an initial C–H metalation followed by an intermolecular migratory insertion into π-bonds and terminated by an electrophilic amination quenching. For intermolecular annulative carboamination reactions which deliver a heterocyclic product, the reader is directed to these well-documented reviews. − This review is ordered by the sources of C- and N-based functionalities and further divided by π-compounds.…”

Ruthenium-Catalyzed Hydroxyl-Directed peri-Selective C–H Activation and Annulation of 1-Naphthols with CF3–Imidoyl Sulfoxonium Ylides for the Synthesis of 2-(Trifluoromethyl)-2,3-dihydrobenzo[de]chromen-2-amines

“…Transition-metal-catalyzed direct C–H bond functionalization has been recognized as a powerful and step-economical approach to access complex heterocycles . In contrast to palladium and rhodium noble-metal catalysts, the utilization of abundant and inexpensive ruthenium or cobalt catalysts in C–H activation reactions has attracted tremendous interest in recent years .…”