Recent Advances in Topical Hemostatic Materials

Abstract

Untimely or improper treatment of traumatic bleeding may cause secondary injuries and even death. The traditional hemostatic modes can no longer meet requirements of coping with complicated bleeding emergencies. With scientific and technological advancements, a variety of topical hemostatic materials have been investigated involving inorganic, biological, polysaccharide, and carbonbased hemostatic materials. These materials have their respective merits and defects. In this work, the application and mechanism of the major hemostatic materials, especially some hemostatic nanomaterials with excellent adhesion, good biocompatibility, low toxicity, and high adsorption capacity, are summarized. In the future, it is the prospect to develop multifunctional hemostatic materials with hemostasis and antibacterial and anti-inflammatory properties for promoting wound healing.

Biochemical Behavior, Influence on Cell DNA Condition, and Microbiological Properties of Wool and Wool–Copper Materials

“…When a foreign body comes into contact with blood, plasma proteins are adsorbed on its surface, which leads to the initiation of the coagulation cascade through the activation of the coagulation factors and the adhesion and activation of platelets. As a result, a fibrin network is formed [ 199 , 200 , 201 , 202 ].…”

Rational Design and Testing of Antibacterial Aloe Vera Hemostatic Hydrogel

“…Its biodegradability, biocompatibility, availability, and low raw material costs enhance its versatility within the medical field. Additionally, the inherent antimicrobial activity and the delivery capability of additional antimicrobial agents offer the potential to prevent secondary infections from contaminated environments, significantly reducing the wound recovery period for patients [ 50 ].…”