Recent Advances in Thermoresponsive OEGylated Poly(amino acid)s

Abstract

Thermoresponsive polymers have been widely studied in the past decades due to their potential applications in biomedicine, nanotechnology, and so on. As is known, poly(N-isopropylacrylamide) (PNIPAM) and poly(oligo(ethylene glycol)methacrylates) (POEGMAs) are the most popular thermoresponsive polymers, and have been studied extensively. However, more advanced thermoresponsive polymers with excellent biocompatibility, biodegradability, and bioactivity also need to be developed for biomedical applications. OEGylated poly(amino acid)s are a kind of novel polymer which are synthesized by attaching one or multiple oligo(ethylene glycol) (OEG) chains to poly(amino acid) (PAA).These polymers combine the great solubility of OEG, and the excellent biocompatibility, biodegradability and well defined secondary structures of PAA. These advantages allow them to have great application prospects in the field of biomedicine. Therefore, the study of OEGylated poly(amino acid)s has attracted more attention recently. In this review, we summarized the development of thermoresponsive OEGylated poly(amino acid)s in recent years, including the synthesis method (such as ring-opening polymerization, post-polymerization modification, and Ugi reaction), stimuli-response behavior study, and secondary structure study. We hope that this periodical summary will be more conducive to design, synthesis and application of OEGylated poly(amino acid)s in the future.

Cyclodextrin-Based Polymeric Drug Delivery Systems for Cancer Therapy

“…Thermoresponsive polymers, exhibiting a reversible phase transition to temperature, have shown great potential in biomedical areas. Thermoresponsive polymers can be classified into LCST (lower critical solution temperature) types and UCST (upper critical solution temperature) types [ 120 , 121 ]. Among them, PNIPAAm (Poly (N-isopropylacrylamide))-based polymers are one of the most widely studied thermoresponsive polymers owing to their intense volume change with a lower LCST (32 °C).…”

Thermoresponsive polymers with LCST transition: synthesis, characterization, and their impact on biomedical frontiers

“…Above LCST, P(MEO 2 MA-co-OEGMA 475 ) copolymer becomes completely opaque due to the aggregation of large particles. Polymers can be decorated with ethylene glycol units on the side chain with various main chains composed of polymethacrylate (POEGMA), 104,110 polyacrylate (POEGA), 45 polystyrene (POEGSt), 111 poly(vinyl ether) (POEGVE), 112 polynorbornene (POEGNB), 113 polyether (POEGE), 114,115 polylactide (POEGLA), 116,117 polymethylene (POEGM), 118 polyphosphazene (PBEEP), 119,120 and poly(amino acid) 121,122 (Fig. 3).…”