Recent advances in therapeutical applications of the versatile hydroxypyridinone chelators

Sharma, Shailza; Baral, Minati; Kanungo, B. K.

doi:10.1007/s10847-021-01114-1

Cited by 1 publication

(2 citation statements)

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“…The exceptional photophysical properties of rhodamines can be complemented with the introduction of receptors, such as 3-hydroxy-4-pyridinone (3,4-HPO) units, allowing the optical detection of several species, namely M(II) and M(III) metal ions [ 15 ]. Indeed, 3,4-HPOs are an important class of N -heterocyclic bidentate ligands, whose use has been widely explored as specific and selective chelators towards environmentally and biologically relevant metals, specially Al 3+ and Fe 3+ [ 16 , 17 , 18 , 19 ]. In this context, the functionalization at the benzoate ring of rhodamine with 3,4-HPO chelating units is being approached as a very promising and useful methodology to obtain fluorescent probes, which can be used in the detection and quantification of such metal ions [ 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, 3,4-HPOs are an important class of N -heterocyclic bidentate ligands, whose use has been widely explored as specific and selective chelators towards environmentally and biologically relevant metals, specially Al 3+ and Fe 3+ [ 16 , 17 , 18 , 19 ]. In this context, the functionalization at the benzoate ring of rhodamine with 3,4-HPO chelating units is being approached as a very promising and useful methodology to obtain fluorescent probes, which can be used in the detection and quantification of such metal ions [ 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Functionalization of Rhodamine Platforms with 3-Hydroxy-4-pyridinone Chelating Units and Its Fluorescence Behavior towards Fe(III)

et al. 2022

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Functionalization of xanthene fluorophores with specific receptor units is an important topic of research aiming for the development of new analytical tools for biological sciences, clinical diagnosis, food and environmental monitoring. Herein, we report a new dihydrorosamine containing two active amino groups, which was functionalized with 3-benzyloxy-1-(3′-carboxypropyl)-2-methyl-4-pyridinone through an amide coupling strategy. Benzylated mono- and di-functionalized dihydrorosamine derivatives (H in position 9 of the xanthene) were obtained, but with modest reaction yields, requiring long and laborious purification procedures. Looking for a more efficient approach, rhodamine 110 was selected to react with the carboxypropyl pyridinone, enabling the isolation of the corresponding mono- and di-functionalized derivatives in amounts that depend on the excess of pyridinone added to the reaction. The structure of all compounds was established by 1H and 13C NMR, MS (ESI) and their absorption and emission properties were evaluated in dichloromethane. The fluorescence behavior of the debenzylated mono-rhodamine 110 derivative in the presence of Fe(III) was studied, making it an interesting fluorogenic dye for future optical sensing applications.

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