Recent Advances in the Therapeutic Strategies of Glioblastoma Multiforme

Aldoghachi, Asraa Faris; Aldoghachi, Ahmed Faris; Bryne, Koen; Ling, King-Hwa; Cheah, Pike See

doi:10.1016/j.neuroscience.2022.03.030

Cited by 40 publications

(28 citation statements)

References 229 publications

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“…Chemotherapeutic drugs, which are crucial to cancer therapy and have been used therapeutically for decades [52], are included in this more general category. Cyclophosphamide, a regularly used alkylating drug with several metabolites that crosslink DNA, is rapidly taken up by rapidly respiring cells, such as tumor cells, and hence has a considerably larger effect on DNA damage in tumor cells than in cells from other organs [53].…”

Section: Cytotoxic Therapies Are Used At All Phases Of the Cell Cyclementioning

confidence: 99%

Cellular and molecular basis of therapeutic approaches to breast cancer

El‐Tanani

Khatib

Al-Najjar

et al. 2023

Cellular Signalling

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Section: Cytotoxic Therapies Are Used At All Phases Of the Cell Cyclementioning

confidence: 99%

Cellular and molecular basis of therapeutic approaches to breast cancer

El‐Tanani

Khatib

Al-Najjar

et al. 2023

Cellular Signalling

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“…Compared with traditional cytotoxic chemotherapeutic agents, TMZ has mild side effects, is well tolerated, and is easy to administer [ 87 , 88 ]. Currently, TMZ-based chemotherapy regimens have been widely used in the adjuvant treatment of high-grade gliomas, in the salvage treatment of recurrent gliomas, and low-grade gliomas with poor prognostic factors [ 89 , 90 ].…”

Section: The Roles Of Texs In Chemoresistancementioning

confidence: 99%

Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma

2022

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Small extracellular vesicles (SEVs) are extracellular vesicles containing DNA, RNA, and proteins and are involved in intercellular communication and function, playing an essential role in the growth and metastasis of tumors. SEVs are present in various body fluids and can be isolated and extracted from blood, urine, and cerebrospinal fluid. Under both physiological and pathological conditions, SEVs can be released by some cells, such as immune, stem, and tumor cells, in a cytosolic manner. SEVs secreted by tumor cells are called tumor-derived exosomes (TEXs) because of their origin in the corresponding parent cells. Glioma is the most common intracranial tumor, accounting for approximately half of the primary intracranial tumors, and is characterized by insidious onset, high morbidity, and high mortality rate. Complete removal of tumor tissues by surgery is difficult. Chemotherapy can improve the survival quality of patients to a certain extent; however, gliomas are prone to chemoresistance, which seriously affects the prognosis of patients. In recent years, TEXs have played a vital role in the occurrence, development, associated immune response, chemotherapy resistance, radiation therapy resistance, and metastasis of glioma. This article reviews the role of TEXs in glioma progression, drug resistance, and clinical diagnosis.

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“…Cancer is a serious threat to human health [ 1 ]. At present, there are many choices for cancer treatment, such as surgical resection, chemotherapy, phototherapy, immunotherapy and gene therapy [ 2 , 3 , 4 , 5 , 6 , 7 ]. In addition to surgical resection, chemotherapy is the most commonly used remedy because of its advantages of antitumor broad-spectrum and systemic therapeutic effects [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Reduction-Hypersensitive Podophyllotoxin Prodrug Self-Assembled Nanoparticles for Cancer Treatment

Wang

et al. 2023

Pharmaceutics

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Podophyllotoxin (PPT) has shown strong antitumor effects on various types of cancers. However, the non-specific toxicity and poor solubility severely limits its clinical transformation. In order to overcome the adverse properties of PPT and explore its clinical potential, three novel PTT−fluorene methanol prodrugs linked by different lengths of disulfide bonds were designed and synthesized. Interestingly, the lengths of the disulfide bond affected the drug release, cytotoxicity, pharmacokinetic characteristics, in vivo biodistribution and antitumor efficacy of prodrug NPs. To be more specific, all three PPT prodrugs could self-assemble into uniform nanoparticles (NPs) with high drug loading (>40%) via the one-step nano precipitation method, which not only avoids the use of surfactants and cosurfactants, but also reduces the systemic toxicity of PPT and increases the tolerated dose. Among the three prodrug NPs, FAP NPs containing α-disulfide bond showed the most sensitive tumor-specific response and fastest drug release rate, thus demonstrating the strongest in vitro cytotoxicity. In addition, three prodrug NPs showed prolonged blood circulation and higher tumor accumulation. Finally, FAP NPs demonstrated the strongest in vivo antitumor activity. Our work will advance the pace of podophyllotoxin towards clinical cancer treatment.

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Recent Advances in the Therapeutic Strategies of Glioblastoma Multiforme

Cited by 40 publications

References 229 publications

Cellular and molecular basis of therapeutic approaches to breast cancer

Cellular and molecular basis of therapeutic approaches to breast cancer

Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma

Reduction-Hypersensitive Podophyllotoxin Prodrug Self-Assembled Nanoparticles for Cancer Treatment

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