Recent advances in the synthesis of pharmaceutically active 4-quinolone and its analogues: a review

Abstract

4-Quinolone and its analogs are heterocyclic classes of organic compounds displaying biologically active and a broad spectrum of pharmaceutical drug scaffolds.

Direct catalytic photodecarboxylative amination of carboxylic acids with diazirines: Divergent access to amines, hydrazines, and nitrogen-containing heterocycles

“…Further, the carbonyl of the (hetero)arene can be an aldehyde or ketone; in the former case, C3 bromination of the products furnishes a well-precedented diversification handle. 14 Several tertiary examples are shown (17,20) that would be inaccessible through traditional SN2 approaches. In a similar vein, indazole 18 was recently described as a part of a TEAD P-site binding fragment screening campaign; it, along with several related derivatives, were prepared in 1-2% yield via alkylation with the appropriate alkyl halides, whereas the diaziridine approach afforded 18 in 53% yield.…”

Synthesis, molecular docking analysis and in vitro evaluation of new heterocyclic hybrids of 4-aza-podophyllotoxin as potent cytotoxic agents

“…20 Owing to the significant role of heterocyclic ring systems in drug discovery and development, many studies have been undertaken to develop biologically active heterocyclic compounds. 21–29…”

“…20 Owing to the signicant role of heterocyclic ring systems in drug discovery and development, many studies have been undertaken to develop biologically active heterocyclic compounds. [21][22][23][24][25][26][27][28][29] Podophyllotoxin, an important plant-derived natural product, has several semisynthetic derivatives such as etoposide, teniposide and etophos, which have been employed in chemotherapy for various cancer types. 30 Although podophyllotoxin and its derivatives have been known as tubulin polymerization or DNA topoisomerase II inhibitors, they are too toxic for therapeutic use and causes some side effects.…”

New 8-hydroxy quinoline-polycyclic aromatic hydrocarbon (PAH) conjugates and their sulfonated derivatives: effects of sulfonation and PAH size on their structural, supramolecular and cytotoxic properties

“…Heterocycles are present in more than 90% of novel drugs, spanning the gap between biology and chemistry. [23][24][25] A typical example of a bicyclic heterocyclic compound is quinoline. Quinolines, characterized by a core structure of fused benzene and pyridine rings, are ubiquitous in natural products.…”