Recent Advances in the Synthesis of Indole and Quinoline Derivatives through Cascade Reactions

Abstract

Indoles and quinolines are ubiquitous structural motifs in many natural products and biologically active pharmaceuticals. The pursuit of synthetic efficiency has stimulated the design and development of new synthetic strategies to construct these heterocycles. One of the most effective ways of achieving efficiency is to implement reaction cascades, enabling multiple bond-forming and bond-cleaving events to occur in a single synthetic operation, thus circumventing the waste associated with traditional stepwise synthesis. In general, cascade reactions offer the opportunity to access highly functionalized final products from simple starting materials. For all these reasons, it is not a surprise that most of the recently reported methods for the synthesis of indoles and quinolines are based on the use of cascade reactions. In this Focus Review we discuss some of the most representative and interesting recent reports on the synthesis of indoles and quinolines through cascade reactions.

One‐Pot Gold‐Catalyzed Synthesis of Azepino[1,2‐a]indoles

“…[4] Some leading metal-assisted examples deal principally with the construction of the pyrrolyl ring with a final C3-functionalization through alkylations [5] or cross-coupling reactions.…”

The Synthesis of Aromatic Heterocycles from Propargylic Compounds

“…[46] Much attention has been focused on developing diverse synthetic methods. [47] The C1-Z cyclization model will be discussed in this section.…”

Potential Biological Activities, Molecular Docking and Synthesis of Novel Ag+, Ni +2 and Fe+3 Complexes with Schiff base N'-(1-(4-((3,4-dihydroquinolin-1(2H)-yl)sulfonyl) phenyl)ethylidene)-3-oxo-3H-benzo[f]chromene-2-carbohydrazide

“…It was concluded that, the biological activities of Schiff bases is increased by complexation [8][9][10][11] . Tetrahydroquinoline derivatives have widely pharmaceuticals applications [12][13][14][15][16][17] . The reactions of tetrahydroquinoline with different derivatives, which lead to modification of its medicinal purpose [18][19][20] .…”