Recent advances in the synthesis of organoselenium heterocycle conjugates

Repurposed organoselenium tethered amidic acids as apoptosis inducers in melanoma cancer via P53, BAX, caspases-3, 6, 8, 9, BCL-2, MMP2, and MMP9 modulations

“…Although significant progress made in the synthesis of OSe compounds, their development has been frequently hindered by different synthetic complications. 44,47 These challenges include the use of complicated reaction conditions ( e.g. absence of O 2 /air or elevated temperature) as well as the hazardous, costly, sensitive, and limited functional group tolerance OSe reagents such as SeOCl 2 , KSeCN, SeCl 4 , and SeF 6 .…”

“…The interest in developing novel OSe candidates is growing stimulated by their privileged antitumor and antioxidant activities. 44–46 Therefore, efficient, and innovative procedures are highly desired to prepare novel functionalized OSe agents and investigate their potential bioactivities. Although significant progress made in the synthesis of OSe compounds, their development has been frequently hindered by different synthetic complications.…”