Recent Advances in the Synthesis and Medicinal Perspective of Pyrazole-Based α-Amylase Inhibitors as Antidiabetic Agents
Rakesh Khator,
Vikramdeep Monga
Abstract:Diabetes is a serious health threat across the globe, claiming millions of lives worldwide. Among the various strategies employed, inhibition of α-amylase is a therapeutic protocol for the management of Type 2 diabetes mellitus. α-Amylase is a crucial enzyme involved in the breakdown of dietary starch into simpler units. However, the clinically used α-amylase inhibitors have various drawbacks. Therefore, design and development of novel α-amylase inhibitors have gained significant attention. The pyrazole motif … Show more
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