Recent advances in the synthesis of chitooligosaccharides and congeners

Enzymatic production of fully deacetylated chitooligosaccharides and their neuroprotective and anti-inflammatory properties

“…The hydrolysis of chitosan can be achieved by physical, chemical or enzymatic methods. The two first require extreme reaction conditions and the composition of the final product is difficult to control (Yang et al 2014). On the other hand, the use of enzymes involves milder conditions (moderate temperature, neutral or slightly acidic pH, atmospheric pressure, etc.)…”

Chitinases as Antibacterial Proteins: A Systematic Review

“…15 The aim of this study was to search the scientific literature for works describing chitinases with antibacterial activity and summarize their main findings, discussing the probable mechanisms responsible for the antibacterial activity of these proteins and their potential applications.…”

From Chitin to Bioactive Chitooligosaccharides and Conjugates: Access to Lipochitooligosaccharides and the TMG‐chitotriomycin

“…8 Given the importance of COSs, a wide range of glycosylation procedures integrated in stepwise or blockwise assembly strategies have been developed for the effective construction of these oligomeric motifs from monomeric glucosamine precursors 5c. 7e, 9, 10…”

“…These are the Nod factors5, 35 (e.g., 30 – 31 ; see Scheme ) and the Myc factors36 (e.g., 32 – 33 ), decisive signal molecules which regulate two ecologically important endo ‐symbioses, the nitrogen‐fixing nodulation of legumes, and the arbuscular mycorrhizal symbiosis of most plants. They have stimulated strong synthetic interest, especially because these molecules are produced by rhizobia or AM fungi as mixtures in very small quantities 7d,e. 19a, 37 They are very similar glycolipids and structurally close to TMG‐chitotriomycin (e.g., 34 ) which is a potent and selective inhibitor of β‐ N ‐acetyl‐hexosaminidases (HexNAcase, EC 3.2.1.52) from fungi, bacteria, and insects 38.…”