Recent Advances in the Synthesis of Dialkyl (Aryl) α-(Aryl/Heterocyclic/Heteroaryl- α-(Aryl/Heteroarylamino)Phosphonates

Abstract

This review describes recent advances that are commonly applied in the synthesis of dialkyl (aryl) αaminophosphonates containing heterocyclic compounds. The target structures are divided into three categories, which include α-aminophosphonic acids and their diesters bearing a heterocyclic or heteroaryl system at the αcarbon, nitrogen atom, or both. The synthetic protocols based on the Kabachnik-Fields and Pudovik reactions as the main pathways for the construction of these features, besides other miscellaneous methods. This review may be a useful resource for researchers and it will help them to work in this emerging research area.